The Basics
What is Methoxsalen?
A psoralen used along with ultraviolet light in a treatment called PUVA to treat vitiligo and psoriasis.
Brand names for Methoxsalen
Oxsoralen-Ultra
How Methoxsalen is classified
Dermatologic Agents, Photosensitizing Agents, Coumarins, Furocoumarins, Psoralens, PUVA Therapy
Methoxsalen During Pregnancy
Methoxsalen pregnancy category
Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Methoxsalen while pregnant
Animal reproduction studies have not been conducted with topical methoxsalen. It is also not known whether methoxsalen can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical methoxsalen is absorbed systemically. Topical methoxsalen should be used in women only when clearly indicated.
Taking Methoxsalen While Breastfeeding
What are recommendations for lactation if you're taking Methoxsalen?
No information is available on the use of methoxsalen during breastfeeding. Expert opinion indicates that due to the photosensitizing effects of methoxsalen, breastfeeding should be withheld for 24 hours after an oral dose to allow for 95% of the drug to be eliminated in the mother’s urine.[1][2] The same precaution probably applies to patients receiving methoxsalen as a part of therapy for cutaneous T-cell lymphoma. Use of topical methoxsalen is not contraindicated during breastfeeding,[3][4] but avoid direct contact of the treated skin with the skin of the infant.
Maternal / infant drug levels
No information is available on the use of methoxsalen during breastfeeding. Expert opinion indicates that due to the photosensitizing effects of methoxsalen, breastfeeding should be withheld for 24 hours after an oral dose to allow for 95% of the drug to be eliminated in the mother’s urine.[1][2] The same precaution probably applies to patients receiving methoxsalen as a part of therapy for cutaneous T-cell lymphoma. Use of topical methoxsalen is not contraindicated during breastfeeding,[3][4] but avoid direct contact of the treated skin with the skin of the infant.
Possible effects of Methoxsalen on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Methoxsalen
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Menter A, Korman NJ, Elmets CA et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol. 2010;62:114-35. PMID: 19811850
2. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II Lactation. J Am Acad Dermatol. 2014;70:417.e1-417.e10. 24528912 PMID: 24528912
3. Reed BR. Dermatologic drugs, pregnancy, and lactation. A conservative guide. Arch Dermatol. 1997;133:894-8. PMID: 9236528
4. Reed BR. Dermatologic drug use during pregnancy and lactation. Dermatol Clin. 1997;15:197-206. PMID: 9001872
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
