Chlorpropamide

The Basics

What is Chlorpropamide?

Used to control high blood sugar in people with type 2 diabetes.

Brand names for Chlorpropamide

Diabinese

How Chlorpropamide is classified

Hypoglycemic Agents, Sulfonylurea Compounds

Chlorpropamide During Pregnancy

Chlorpropamide pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Chlorpropamide while pregnant

Animal reproductive studies have not been conducted with DIABINESE (chlorpropamide) . It is also not known whether DIABINESE (chlorpropamide) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. DIABINESE (chlorpropamide) should be given to a pregnant woman only if the potential benefits justify the potential risk to the patient and fetus. Because data suggest that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, many experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible.

Taking Chlorpropamide While Breastfeeding

What are recommendations for lactation if you're taking Chlorpropamide?

Limited data indicate that amounts of chlorpropamide in breastmilk are unlikely to affect a breastfed infant. Short-acting drugs are generally preferred while breastfeeding a neonate to avoid drug accumulation. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Maternal / infant drug levels

Limited data indicate that amounts of chlorpropamide in breastmilk are unlikely to affect a breastfed infant. Short-acting drugs are generally preferred while breastfeeding a neonate to avoid drug accumulation. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Possible effects of Chlorpropamide on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Chlorpropamide

Acarbose, Glipizide, Glyburide, Insulin, Metformin, Miglitol.