The Basics
What is Oxacillin?
Penicillin used to treat infections caused by certain bacteria.
Brand names for Oxacillin
Oxacillin
How Oxacillin is classified
Anti-Infective Agents, Antibacterial Agents, Penicillins
Oxacillin During Pregnancy
Oxacillin pregnancy category
Category BNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Oxacillin while pregnant
N/A
Taking Oxacillin While Breastfeeding
What are recommendations for lactation if you're taking Oxacillin?
Limited information indicates that oxacillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Oxacillin is acceptable in nursing mothers.
Maternal / infant drug levels
Limited information indicates that oxacillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Oxacillin is acceptable in nursing mothers.
Possible effects of Oxacillin on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Oxacillin
(Methicillin-resistant Staph. aureus) Doxycycline, Linezolid, Minocycline, Trimethoprim-Sulfamethoxazole, Vancomycin.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Prigot A, Froix CJ, Rubin E. Absorption, diffusion, and excretion of a new penicillin, oxacillin. Antimicrob Agents Annu. 1962;2:402-10.
2. Borderon E, Soutoul JH et al. [Excretion of antibiotics in human milk]. Med Mal Infect. 1975;5:373-6.
3. Peiker G, Schroder S. [The concentration of oxacillin and ampicillin (Penstabil) in mother’s milk in puerperal mastitis.] Pharmazie. 1986;41:793-5. PMID: 3562514
4. Kulakov VI, Zak IR, Kulikova NN, Smekuna FA. [Body pharmacokinetics of methicillin, oxacillin and cephaloridine in puerperal mastitis]. Antibiotiki. 1981;26:110-3. PMID: 7212690
5. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732
6. Zhang Y, Zhang Q, Xu Z. [Tissue and body fluid distribution of antibacterial agents in pregnant and lactating women]. Zhonghua Fu Chan Ke Za Zhi. 1997;32(5):288-92. PMID: 9596854
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
