The Basics
What is Rasagiline?
Used alone or with other medications to treat symptoms of Parkinson’s disease.
Brand names for Rasagiline
Azilect
How Rasagiline is classified
Antiparkinson Agents, Monoamine Oxidase Inhibitors, Neuroprotective Agents
Rasagiline During Pregnancy
Rasagiline pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Rasagiline while pregnant
N/A
Taking Rasagiline While Breastfeeding
What are recommendations for lactation if you're taking Rasagiline?
No clinical use of rasagiline during breastfeeding has been reported. Rasagiline might reduce serum prolactin and interfere with milk production. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Maternal / infant drug levels
No clinical use of rasagiline during breastfeeding has been reported. Rasagiline might reduce serum prolactin and interfere with milk production. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Possible effects of Rasagiline on milk supply
Animal studies show that rasagiline reduces serum prolactin. The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Possible alternatives to Rasagiline
Selegiline.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Bauer RL, Orfei J, Wichman CL. Use of transdermal selegiline in pregnancy and lactation: A case report. Psychosomatics. 2017;58:450-2. PMID: 28501290
2. Kupsch A, Oertel WH. Selegiline, pregnancy, and Parkinson’s disease. Mov Disord. 1998;175-6. PMID: 9452347
3. Calabresi P, Silvestrini M, Stratta F et al. l-Deprenyl test in migraine: neuroendocrinological aspects. Cephalalgia. 1993;13:406-9. PMID: 8313454
4. Kodesh A, Weizman A, Aizenberg D et al. Selegiline in the treatment of sexual dysfunction in schizophrenic patients maintained on neuroleptics: a pilot study. Clin Neuropharmacol. 2003;26:193-5. PMID: 12897639
5. Perenyi A, Bagdy G, Arato M. An early phase II trial with L-deprenyl for the treatment of neuroleptic-induced parkinsonism. Pharmacopsychiatria. 1983;16:143-6. PMID: 6140692
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
