The Basics
What is Molindone?
Used to treat the symptoms of schizophrenia.
Brand names for Molindone
Moban
How Molindone is classified
Antipsychotic Agents
Molindone During Pregnancy
Molindone pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Molindone while pregnant
N/A
Taking Molindone While Breastfeeding
What are recommendations for lactation if you're taking Molindone?
Because there is no published experience with molindone during breastfeeding, other antipsychotic agents are preferred.
Maternal / infant drug levels
Because there is no published experience with molindone during breastfeeding, other antipsychotic agents are preferred.
Possible effects of Molindone on milk supply
Galactorrhea has been reported with molindone.[1][2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3][4][5] The hyperprolactinemia is caused by the drug’s dopamine-blocking action in the tuberoinfundibular pathway.[6] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Possible alternatives to Molindone
Haloperidol, Risperidone.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Wesp CE Jr, Annitto W, Feinsod R. Galactorrhea associated with molindone. Am J Psychiatry. 1979;136:975. PMID: 572143
2. Kahn JL. More on galactorrhea associated with molindone. Am J Psychiatry. 1979;136:1617-8. Letter. PMID: 574364
3. Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972;130:349-54. PMID: 4560178
4. Turkington RW. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972;34:62-6. PMID: 5061776
5. Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976;33:279-86. PMID: 1259521
6. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID: 11913677
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
