Pasireotide

The Basics

What is Pasireotide?

An orphan drug approved in the United States for the treatment of Cushing’s disease in patients who fail or are ineligible for surgical therapy.

Brand names for Pasireotide

Signifor, Signifor Lar

How Pasireotide is classified

Hormones, Somatostatin Analogs and Derivatives

Pasireotide During Pregnancy

Pasireotide pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Pasireotide while pregnant

N/A

Taking Pasireotide While Breastfeeding

What are recommendations for lactation if you're taking Pasireotide?

The excretion of pasireotide into breastmilk has not been studied. However, because it has a high molecular weight of 1047 daltons it is likely to be poorly excreted into breastmilk and it is a peptide that is likely digested in the infant’s gastrointestinal tract. It is unlikely to reach the clinically important levels in infant serum. However, the manufacturer states that nursing mothers should not use pasireotide.

Maternal / infant drug levels

The excretion of pasireotide into breastmilk has not been studied. However, because it has a high molecular weight of 1047 daltons it is likely to be poorly excreted into breastmilk and it is a peptide that is likely digested in the infant’s gastrointestinal tract. It is unlikely to reach the clinically important levels in infant serum. However, the manufacturer states that nursing mothers should not use pasireotide.

Possible effects of Pasireotide on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Pasireotide

Octreotide.