The Basics
What is Nizatidine?
Inhibits stomach acid production.
Brand names for Nizatidine
Axid
How Nizatidine is classified
Anti-Ulcer Agents, Histamine H2 Antagonists, Gastrointestinal Agents
Nizatidine During Pregnancy
Nizatidine pregnancy category
Category BNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Nizatidine while pregnant
Oral reproduction studies in pregnant rats at doses up to 1500 mg/kg/day (9000 mg/m2/day, 40.5 times the recommended human dose based on body surface area) and in pregnant rabbits at doses up to 275 mg/kg/day (3245 mg/m2/day, 14.6 times the recommended human dose based on body surface area) have revealed no evidence of impaired fertility or harm to the fetus due to nizatidine. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Taking Nizatidine While Breastfeeding
What are recommendations for lactation if you're taking Nizatidine?
Because of the low levels of nizatidine in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required. Histamine H2-antagonists with more extensive use might be preferred in newborns.
Maternal / infant drug levels
Because of the low levels of nizatidine in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required. Histamine H2-antagonists with more extensive use might be preferred in newborns.
Possible effects of Nizatidine on milk supply
Histamine H2-receptor blockade is known to stimulate prolactin secretion.[2] No reports of hyperlproactinemia, galactorrhea or effects on breastfeeding women caused by nizatadine were found as of the revision date. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Possible alternatives to Nizatidine
Cimetidine, Famotidine, Omeprazole, Pantoprazole, Ranitidine, Sucralfate.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Obermeyer BD, Bergstrom RF, Callaghan JT et al. Secretion of nizatidine into human breast milk after single and multiple doses. Clin Pharmacol Ther. 1990;47:724-30. PMID: 1972674
2. Knigge UP. Histaminergic regulation of prolactin secretion. Dan Med Bull. 1990;37:109-24. PMID: 2188799
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
