Lomefloxacin

The Basics

What is Lomefloxacin?

Used to treat chronic bronchitis, as well as complicated and uncomplicated urinary tract infections. It is also used as a preventative treatment to prevent urinary tract infections in patients undergoing transrectal or transurethral surgical procedures.

Brand names for Lomefloxacin

Lomefloxacin

How Lomefloxacin is classified

Anti-Infective Agents, Antibacterial Agents, Quinolones, Fluoroquinolones

Lomefloxacin During Pregnancy

Lomefloxacin pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Lomefloxacin while pregnant

Reproductive function studies have been performed in rats at doses up to 8 times the recommended human dose based on mg/m² (34 times the recommended human dose based on mg/kg), and no impaired fertility or harm to the fetus was reported due to lomefloxacin. Increased incidence of fetal loss in monkeys has been observed at approximately 3 to 6 times the recommended human dose based on mg/m² (6 to 12 times the recommended human dose based on mg/kg). No teratogenicity has been observed in rats and monkeys at up to 16 times the recommended human dose exposure. In the rabbit, maternal toxicity and associated fetotoxicity, decreased placental weight, and variations of the coccygeal vertebrae occurred at doses 2 times the recommended human exposure based on mg/m². There are, however, no adequate and well-controlled studies in pregnant women. Lomefloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Taking Lomefloxacin While Breastfeeding

What are recommendations for lactation if you're taking Lomefloxacin?

No information is available on the use of lomefloxacin during breastfeeding. Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants’ developing joints. However, recent studies indicate little risk.[1][2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk,[3] but insufficient data exist to prove or disprove this assertion. Use of lomefloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). However, it is preferable to use an alternate drug for which safety information is available.

Maternal / infant drug levels

No information is available on the use of lomefloxacin during breastfeeding. Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants’ developing joints. However, recent studies indicate little risk.[1][2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk,[3] but insufficient data exist to prove or disprove this assertion. Use of lomefloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). However, it is preferable to use an alternate drug for which safety information is available.

Possible effects of Lomefloxacin on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Lomefloxacin

Ciprofloxacin, Levofloxacin.