The Basics
What is Daptomycin?
Used to treat certain blood infections or serious skin infections caused by bacteria in adults and children (1+).
Brand names for Daptomycin
Cubicin
How Daptomycin is classified
Anti-Infective Agents, Antibacterial Agents, Peptides, Cyclic, Lipopeptides
Daptomycin During Pregnancy
Daptomycin pregnancy category
Category BNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Daptomycin while pregnant
There are no adequate and well-controlled trials of CUBICIN in pregnant women. Embryofetal development studies performed in rats and rabbits at doses of up to 75 mg/kg (2 and 4 times the 6 mg/kg human dose, respectively, on a body surface area basis) revealed no evidence of harm to the fetus due to daptomycin. Because animal reproduction studies are not always predictive of human response, CUBICIN should be used during pregnancy only if the potential benefit outweighs the possible risk.
Taking Daptomycin While Breastfeeding
What are recommendations for lactation if you're taking Daptomycin?
Limited and somewhat inconsistent information indicates that daptomycin produces very low levels in milk and it would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Maternal / infant drug levels
Limited and somewhat inconsistent information indicates that daptomycin produces very low levels in milk and it would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Possible effects of Daptomycin on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Daptomycin
Vancomycin.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Buitrago MI, Crompton JA, Bertolami S et al. Extremely low excretion of daptomycin into breast milk of a nursing mother with methicillin-resistant Staphylococcus aureus pelvic inflammatory disease. Pharmacotherapy. 2009;29:347-51. PMID: 19249952
2. Cesari E, Roda G, Visconti GL et al. Daptomycin excretion into human milk. Br J Clin Pharmacol. 2018;84:394-5. PMID: 29172024
3. Dei Cas M, Casagni E, Gambaro V et al. Determination of daptomycin in human plasma and breast milk by UPLC/MS-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2019;1116:38-43. PMID: 30953921
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
