Oxaprozin

The Basics

What is Oxaprozin?

Used to treat arthritis and reduces pain, swelling, and stiffness of the joints.

Brand names for Oxaprozin

Daypro Alta

How Oxaprozin is classified

Analgesic Agents, Nonsteroidal Antiinflammatory Agents

Oxaprozin During Pregnancy

Oxaprozin pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Oxaprozin while pregnant

Use of NSAIDs, including DAYPRO ALTA, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Avoid use of NSAIDs, including DAYPRO ALTA, in pregnant women starting at 30 weeks of gestation (third trimester). There are no adequate and well-controlled studies of DAYPRO ALTA in pregnant women. Data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive. In the general U.S. population, all clinically recognized pregnancies, regardless of drug exposure, have a background rate of 2-4% for major malformations, and 15-20% for pregnancy loss. In animal reproduction studies, oral administration of oxaprozin to pregnant rabbits at doses 0.1-times the maximum daily human dose (based on body surface area) resulted in evidence of teratogenicity; however, oral administration of oxaprozin to pregnant mice and rats during organogenesis at doses equivalent to the maximum recommended human dose revealed no evidence of teratogenicity or embryotoxicity. In rat reproduction studies in which oxaprozin was administered through late gestation failure to deliver and a reduction in live birth index was observed at doses equivalent to the maximum recommended human dose. Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. In animal studies, administration of prostaglandin synthesis inhibitors such as oxaprozin potassium, resulted in increased pre- and post-implantation loss.

Taking Oxaprozin While Breastfeeding

What are recommendations for lactation if you're taking Oxaprozin?

Because there is no published experience with oxaprozin during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Because there is no published experience with oxaprozin during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Oxaprozin on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Oxaprozin

Ibuprofen, Flurbiprofen, Piroxicam.