Amyl Salicylate

The Basics On Amyl Salicylate

What is Amyl Salicylate?

Fragrant component.

What are other names for Amyl Salicylate?

2-HYDROXY- PENTYL ESTER BENZOIC ACID, 2-HYDROXYBENZOIC ACID, PENTYL ESTER, AMYL SALICYLATE, BENZOIC ACID, 2-HYDROXY-, PENTYL ESTER, BENZOIC ACID, 2HYDROXY, PENTYL ESTER, PENTYL ESTER 2-HYDROXYBENZOIC ACID, PENTYL ESTER BENZOIC ACID, 2-HYDROXY-, PENTYL ESTER SALICYLIC ACID, PENTYL SALICYLATE, and SALICYLIC ACID, PENTYL ESTER

What is Amyl Salicylate used for?

Benzyl salicylate is an ester formed by the esterification of salicylic acid with benzyl alcohol. It is used as a fragrance enhancer in skincare products. … Benzyl salicylate is one of a number of cosmetic fragrance additives which can cause varying degrees of contact dermatitis in sensitive skin types.

How Amyl Salicylate is classified

Fragrance: Synthetic and Fragrant Plant Extracts

Recommendations for using Amyl Salicylate during pregnancy and breastfeeding

Avoid

 

Amyl Salicylate During Pregnancy

What we know about using Amyl Salicylate while pregnant or breastfeeding

Limited information available.

In Vitro Salicylic Acid Post-implantation rat embryos of day 11 were cultured for 24 h with 10, 100, or 1000 Œºg/ml Salicylic Acid. 40 The growth and developmental of each embryo was evaluated and compared with control embryos for the presence of any malformations. Salicylic Acid decreased all growth and developmental parameters in a concentration-dependent manner, when compared with controls. However, exposure to Salicylic Acid at 10 Œºg/ml culture did not show any significant effect on embryonic growth and development. Parallel to this, flow cytometric analysis (cell cycle and annexin V binding) and DNA fragmentation assay were carried out followed by quantitation by 3 π-OH labeling of cultured rat embryos to evaluate the role of apoptosis in bringing about Salicylic Acid-induced teratogenesis. All results were found to be dose-dependent and an increase in apoptosis in embryonic tissues may be related to the increased risk of congenital malformations. The data suggested that apoptosis might be involved in mediating teratogenesis of Salicylic Acid in vitro. Salicylic Acid and Sodium Salicylate The effects of Salicylic Acid and Sodium Salicylate on early organogenesis and the interaction of these chemicals with free radicals was investigated.41 Post-implantation Wistar rat embryos were cultured in vitro) from day 9.5 of gestation for 48 h; each test substance was added to whole rat serum at concentrations between 0.1 and 0.6 mg/ml. Also, each test Distributed for comment only — do not cite or quote substance (0.3 mg/ml) was added to the culture media in the presence of superoxide dismutase (30 U/ml) or glutathione (0.5 ¬µmol/ml). The growth and development of embryos was compared, and each embryo was evaluated for the presence of malformations. When compared to the growth of control embryos, both chemicals decreased all growth and developmental parameters in a concentration-responsive manner. There was also a concentration-related increase in overall dysmorphology, including the following: hematoma in the yolk sac and neural system, open neural tube, abnormal tail torsion, and the absence of forelimb bud. When superoxide dismutase was added in the presence of Salicylic Acid, the incidence of malformations was decreased. However, the addition of superoxide dismutase did not affect the growth and developmental parameters of Salicylic Acid and Sodium Salicylate. The authors noted that the effects of salicylates might involve free oxygen radicals by the non-enzymatic production of the highly teratogenic metabolites 2,3-dihydroxybenzoic acid and 2,5-dihydroxybenzoic acid. Furthermore, they noted that an enhanced production of these metabolites in embryonic tissues may be directly related to the increased risk of congenital malformations. Animal Dermal Methyl Salicylate Dermal exposure to Methyl Salicylate is associated with reproductive and developmental toxicity as a function of blood levels reached as a result of exposure. 1 Oral Methyl Salicylate, Salicylic Acid, and Sodium Salicylate Salicylic Acid, produced when aspirin is rapidly hydrolyzed to Salicylic Acid after absorption from the gut, was reported to be the causative agent in aspirin teratogenesis in animals. 1 Oral exposure to Methyl Salicylate, Salicylic Acid, and Sodium Salicylate are associated with reproductive and developmental toxicity as a function of blood levels reached as a result of exposure. Sodium Salicylate Groups of 15 mated Crl:CD (SD)BR rats were given a single dose of 0 or 300 mg/kg (dose volume = 10 ml/kg) Sodium Salicylate (99.5% pure, in distilled water) on gestation day (GD) 9. 42 All fetal data, including all supernumerary ribs data, are presented as the percentage mean per litter. No statistical analysis was carried out on mean incidences of supernumerary ribs and the number of presacral vertebrae. In the treated group, adverse effects were noted on body weight changes and food consumption during the 2 days following dosing. At birth, a high majority of pups had extra ribs at the 300 mg/kg dose. Specifically, on postnatal day 1, 89% of pups from dams exposed to 300 mg/kg Sodium Salicylate had supernumerary ribs. For these pups, evidence of postnatal reversibility was observed in 10 out of 14 pups with rudimentary ribs and 26 presacral vertebrae. Radiographs done on postnatal days 1, 6, 14, 28 and 54 showed a reduction in the incidence of rudimentary ribs only, whereas extra ribs, often associated with 27 presacral vertebrae, had the same incidence from birth to adult stage. Furthermore, extra ribs seemed to exhibit similar growth evolution to the other thoracic ribs. The authors noted that dosing with Sodium Salicylate resulted in a significant increase in the incidence of supernumerary ribs. The length of gestation was not affected by treatment. At birth, the number of dead pups was slightly higher in the treated group (7 dead pups out of 15 litters) in comparison with the control group (3 out of 14 litters) but no external malformations were significantly increased in the treated group. In a study involving mated female Sprague-Dawley rats, Sodium Salicylate was administered by gavage on GD 9 (day of vaginal plug or sperm in vaginal smears was designated gestation day (GD) 0) at a dose of 300 mg/kg (in distilled water).43 Control animals received distilled water only. The females were killed on GD 13. The mean number of live embryos was slightly lower than the control group value (11.9 as compared to 14.7), mainly due to a slight, but nonsignificant, increased number of early resorptions in the treated group. Because Sodium Salicylate is known to cause an increased incidence of supernumerary ribs (see preceding study), the molecular basis of this defect was evaluated in this study by analyzing the possible involvement of Hox genes, known to specify vertebrae identity. On GD 13, the expression of several Hox genes, selected according to the position of their anterior limit of expression, namely upstream (Hoxa9), at the level (Hoxa10) and downstream (Hoxd9) to the morphological alteration, were analyzed. Posterior shifts in the anterior limit of expression of Hoxa10 and Hoxd9 were observed following exposure to Sodium Salicylate, which could explain an effect at the level of the axial skeleton. This finding suggests that the appearance of ectopic ribs can be attributed to an anterior transformation of lumbar vertebrae identity into thoracic vertebrae identity. The authors noted that whether this transformation occurs with all compounds inducing supernumerary ribs in rats remains to be determined. Distributed for comment only — do not cite or quote Sodium Salicylate served as the positive control in an embryo-fetal developmental toxicity study.44 The positive control (in distilled water) was administered intragastrically (dose = 250 mg/kg/day; once daily) to a group of 22 to 24 gravid female Sprague-Dawley rats on GDs 8 to 10. Sodium Salicylate was administered at a dose volume of 10 ml/kg/day. There were 4.8% malformations in fetuses from the positive control group, including exencephaly, cranial meningocele, spina bifida, gastroschisis, and subcutaneous ecchymosis. The rate of abnormality was significantly higher than that of the vehicle control group (p < 0.01). Additionally, there were significant difference in the body and tail length, and mean body weight of fetuses in positive control group compared with the vehicle control group (p < 0.01). Human Dermal Salicylic Acid In the third trimester, the use of Salicylic Acid can potentially cause early closure of ductus arteriosus and oligohydramnios. Therefore, it should not be applied over large surface areas for prolonged time periods, or under occlusive dressings that may enhance systemic absorption.45,46 (The primary reference upon which these statements are based has been ordered for further details.) Oral Salicylic Acid An exposure assessment of a representative cosmetic product (containing ‚⧠2% Salicylic Acid) used on a daily basis is available which estimates that the exposure from the cosmetic product would be only 20% of the level seen with ingestion of a ‚Äúbaby‚Äù aspirin (81 mg) on a daily basis. This exposure assessment further contends that the reproductive and developmental toxicity from the daily use of a baby aspirin is not significant.

General safety info about Amyl Salicylate from CIR

No report found.

Use this, not that!

Coming soon!

Products where you might find Amyl Salicylate

Erborian CC Cream Radiance Color Corrector Broad Spectrum SPF25; Erborian CC Cream Radiance Color Corrector Broad Spectrum SPF25 Mini