The Basics On Methylchloroisothiazolinone
What is Methylchloroisothiazolinone?
Preservative that’s active against bacteria, yeast, and fungi; have an active sulphur moiety that is able to oxidize thiol-containing residues.
What are other names for Methylchloroisothiazolinone?
3(2H)ISOTHIAZOLONE, 5CHLORO2METHYL, 4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-, 5-CHLORO-2-METHYL- 4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-2H-ISOTHIAZOL-3-ONE, 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE, METHYLCHLOROISOTHIAZOLINONE, and METHYLCHLOROTHIAZOLINONE
What is Methylchloroisothiazolinone used for?
How Methylchloroisothiazolinone is classified
Preservatives, Sensitizing
Recommendations for using Methylchloroisothiazolinone during pregnancy and breastfeeding
Avoid
Methylchloroisothiazolinone During Pregnancy
What we know about using Methylchloroisothiazolinone while pregnant or breastfeeding
Limited information available.
MCI/MI administered by gavage to pregnant rabbits (gestation days 6 through 18) at doses up to 13.3 mg/kg/day was toxic to the dam, embryo, and fetus; the compound was not teratogenic. 1 In pregnant rats (gestation days 5 through 15) that received MCI/MI at doses up to 15 mg/kg/day, toxicity was observed in the dams, but no treatment-related effects were noted in any of the reproductive parameters of the surviving dams and fetuses and no teratogenicity was observed.
General safety info about Methylchloroisothiazolinone from CIR
The Cosmetic Ingredient Review (CIR) Expert Panel reassessed the safety of the mixture Methylchloroisothiazolinone (MCI)/Methylisothiazolinone (MI), which functions as a preservative in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessment of this mixture, and concluded that MCI/MI is safe in cosmetics when formulated to be nonsensitizing, based on the results of a quantitative risk assessment (QRA) or similar methodology; however, at no point should concentrations exceed 7.5 ppm in leave-on products or 15 ppm in rinse-off products.
Use this, not that!
Coming soon!
Products where you might find Methylchloroisothiazolinone
Maison Louis Marie Le Bouquet Candle Trio Set; Maison Louis Marie Antidris Cassis Candle; Maison Louis Marie No. 09 Vallee de Farney Candle
List of References
General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
N/A
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
