Idebenone

The Basics On Idebenone

What is Idebenone?

A synthetic antioxidant similar to coenzyme Q10.

What are other names for Idebenone?

6-(10-HYDROXYDECYL) UBIQUINONE, HYDROXYDECYL UBIQUINONE, and IDEBENONE

What is Idebenone used for?

Idebenone is a synthetic analog of, and similar in structure to, the potent antioxidant ubiquinone, or coenzyme Q10. It has a lower molecular weight and is presumed to penetrate the skin more efficiently than its parent compound1. Is Idebenone good for my skin? Idebenone has been found to possess powerful antioxidative properties and may offer the following benefits to our skin: Antioxidant protection against actions of oxidative free radicals A recent study was conducted to compare the oxidative stress protective capacity of commonly used antioxidants. Results compared the oxidative capacity of L-ascorbic acid, dl-alpha-tocopherol, kinetin, dl-alpha-lipoic acid, ubiquinone, and idebenone2. This study results showed that Idebenone had the most effective overall oxidative stress protection capacity of this antioxidant group2. Treatment of photodamaged skin In another study to establish the efficacy of idebenone in a topical skincare formulation for the treatment of photodamaged skin, idebenone at 0.5% and 1.0% was applied topically. After six weeks, the 0.5% idebenone formulation, saw a 23% reduction in skin roughness/dryness, a 37% increase in skin hydration, a 27% reduction in fine lines/wrinkles, and a 30% improvement in overall global assessment of photodamaged skin3. the 1.0% idebenone formula saw a 26% reduction in skin roughness/dryness, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. Conclusions Idebenone has shown excellent potential as a skin antioxidant and free radical protecting agent and as a treatment for the effects of photodamaged skin.

How Idebenone is classified

Antioxidants

Recommendations for using Idebenone during pregnancy and breastfeeding

Limited data suggests no known risk

 

Idebenone During Pregnancy

What we know about using Idebenone while pregnant or breastfeeding

Limited information available.

No adverse effects on fertility or reproductive performance were observed in a study in which male and female Wistar rats were dosed orally with up to 500 mg/kg bw Hydroxydecyl Ubiquinone prior to mating, during gestation, and until day 22 post-partum.47 In several other studies, no statistically significant adverse effects upon reproductive performance or fetal development were seen in rats dosed at up to 1000 mg/kg/d Hydroxydecyl Ubiquinone, although a higher incidence of post-implantation loss was reported in some studies.3,4 The NOAELs, based on body surface area comparisons, were determined to be up to 1000 mg/kg/d for embryofetal development, and 500 mg/kg/d and 1000 mg/kg/d, for male and female fertility, respectively.4 Rabbits, dosed at up to 150 mg/kg/d Hydroxydecyl Ubiquinone and observed for teratological abnormalities, displayed chromaturia in the highest dosage group.3 In Japanese rabbits dosed at up to 500 mg/kg/d Hydroxydecyl Ubiquinone, one abortion was observed in the highest dosage group, but was not considered significant due to the spontaneous abortion rate in the animal strain; no statistically significant embryofetal differences were reported between controls and treated groups.4 No treatment-related changes were observed in the F1 generation, or in the dams, of rats dosed at up to 500 mg/kg/d Hydroxydecyl Ubiquinone.3,4 The NOAEL for rat pup development was determined to be 500 mg/kg/d Hydroxydecyl Ubiquinone.4Treatment with Ubiquinone had no effect on fetal death, weight, or postnatal toxicity in primigravid mice (strain and number not specified) dosed at up to 600 mg/kg/d, from day 7 to day 13 of gestation.30 Groups of 10 male mice were given up to 10,000 mg/kg bw U biquinone, via gavage, for 5 d, followed by a 35-d latency period, to test for defects in sperm morphology.49 No significant differences were found in the incidence of sperm abnormalities between Ubiquinone-treated mice and the negative controls (treated with corn oil). Except for an increase in seminiferous epithelium heights, no biochemical, histological, o r morphological differences were observed between 8 male Wistar rats dosed at 10 mg/kg bw/d Ubiquinone for 14 d and negative control and vehicle control groups.51 Treatment with Ubiquinone had no effect on fetal death, weight, or postnatal activity in primigravid rats dosed at up to 600 mg/kg/d, from day 9 to day 15 of gestation.

General safety info about Idebenone from CIR

No report found.

Use this, not that!

Products where you might find Idebenone

Elizabeth Arden PREVAGE® Anti-Aging Daily Serum; Estee Lauder NightWear Plus Anti-Oxidant Night Detox Creme