The Basics On Azulene

What is Azulene?

Chamomile extract used primarily as a coloring agent in cosmetics.

What are other names for Azulene?

AZULENE and CYCLOPENTACYCLOHEPTENE

What is Azulene used for?

Used in salves and ointments, azulene will help to calm a wide variety of skin conditions and irritations because of its soothing, antibacterial and anti-inflammatory properties. As azulene is an herbal ingredient, many of its properties are thought to be derived from the chamomile plant, through which it is distilled.

How Azulene is classified

Skin-Soothing, Plant Extracts, Antioxidants

Recommendations for using Azulene during pregnancy and breastfeeding

Limited data suggests no known risk

 

Azulene During Pregnancy

What we know about using Azulene while pregnant or breastfeeding

Limited information available.

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General safety info about Azulene from CIR

Azulene is an extract from the volatile oil of several perennial herbs and is detected in tobacco smoke. It functions as a skin conditioning agent in cosmetic formulations, including hair dyes. Azulene is reported to be used in a wide range of cosmetic formulations, but these reported uses are likely to be uses of guaiazulene, a chemically related colorant, because there are currently no suppliers of Azulene to the cosmetics industry. The anti-inflammatory action of Azulene has been demonstrated in several animal studies. Effects at the cellular level are reported to include inhibition of respiration and growth, but no effect on ciliary activity or membrane permeability. Relatively low oral toxicity was seen in acute animal studies. Azulene was not mutagenic in an Ames test, with and without metabolic acfivation. An allergic response to Azulene was noted in one case report. These data were clearly insufficient to support the safety of Azulene in cosmetics. Additional data needed to make a safety assessment include: methods of manufacture and impurities, especially naphthalenes; current concentration of use; skin penetration, if there is significant skin penetration, then both a 28-day dermal toxicity study to assess general skin and systemic toxicity and a reproductive and developmental toxicity study are needed; one genotoxicity study in a mammalian system, if positive, then a 2-year dermal carcinogenesis study using National Toxicology Program methods is needed; skin irritation and sensitization in animals or humans; and ocular toxicity.

Use this, not that!

Products where you might find Azulene

GROWN ALCHEMIST Soothing Body Gel-Lotion – Allantoin, Azulene, K+Mg Aspartate (6.76 fl. oz.); SUNDAY RILEY Luna Retinol Sleeping Night Oil; Herbivore Blue Tansy Resurfacing Clarity Mask; SUNDAY RILEY Multivitamins Set

 

 

 

List of References

General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/

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Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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