Cholesterol

The Basics On Cholesterol

What is Cholesterol?

The surface of skin depends on the stratum corneum lipid matrix.

What are other names for Cholesterol?

CHOLEST-5-EN-3-OL (3.BETA.)-, CHOLEST-5-EN-3-OL (3B)-, CHOLEST5EN3OL (3 ), CHOLESTERIN, CHOLESTEROL, CHOLESTERYL ALCOHOL, and PROVITAMIN D

What is Cholesterol used for?

Cholesterol is a very important component of the skin and plays a crucial role in the structure and function of our skin barrier. The lipid lamellar membrane between skin cells is composed of 25% cholesterol and the skin requires an abundance of cholesterol to function correctly. Cholesterol is also important in the internal functioning of the keratinocytes and their transformation into corneocytes. As well as adding to cholesterol in the lipid membrane, topical application of cholesterol increases cholesterol content in keratinocytes as cholesterol can traverse the lipid membrane.

How Cholesterol is classified

Emollients, Skin-Replenishing

Recommendations for using Cholesterol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Cholesterol During Pregnancy

What we know about using Cholesterol while pregnant or breastfeeding

Limited information available.

There has been much interest among dental scientists in the teratogenic effect of Cholesterol. Steroids, including Cholesterol, are capable of experimentally inducing oral cleft anomalies in the rat. Two groups of 10 female albino rats were used in a study to evaluate the ability of Cholesterol to induce cleft palate. One group received a daily subcutaneous injection of 15 mg Cholesterol in 2 ml vegetable oil, and the other group received a 2 ml injection of vegetable oil only. Both groups received injections from the 8th through the 14th day of pregnancy. Dams were killed on the 18th day of pregnancy, and fetuses were removed and evaluated for gross and histological oral anomalies. Seven of the 10 control animals were pregnant, with an average of 12.5 pups per dam. No malformations were found in control offspring. In the test group, 5 of the 10 rats were pregnant, with an average of 10 pups per litter. Fifty-seven percent of the fetuses from the test group had abnormal palates. (86) Buresh and Urban continued these experiments with lower doses of Cholesterol. Following the procedure outlined above, controls had no cleft malformations, and fetuses from dams receiving daily injections of 5 mg or 10 mg Cholesterol .had 27% and 52% incidences of palate 502 COSMETIC INGREDIENT REVIEW anomalies, respectively. (*‘) Cleft palate fetal malformations have also been experimentally induced in Sprague-Dawley rats with 15 mg and 20 mg Cholesterol injections to the dams on Days 7 through 14 of gestation.(8*) Two inhibitors of Cholesterol synthesis [l-(p-(2-diethylaminoethoxy)phenyl)- 1-(p-totyl)-2-(chlorphenyl) ethanol and trans 1,4-bis(2-dichlorobenzyl-aminoethyl) cyclohexane dihydrochloride] have produced teratogenicity and embryotoxicity jn rats. The malformations most commonly observed were of the holoprosencephalic type: cyclocephaly, cyclopia, monorhinia, and hypoplasia or aplasia of the pituitary. There were also some urogenital anomalies. The holoprosencephalic deformities were prevented by a concurrent (maternal) hypercholesterolemia-provoking diet.(8g-g2)

General safety info about Cholesterol from CIR

Cholesterol is used as an emulsifier In cosmetic skin and hair care products and eye and face makeup formulations at concentrations up to 546. The normal metabolism and excretion of Cholesterol is well documented in man and experimental animals. Cholesterol IS not a significant dermal or ocular irritant. Cholesterol does not appear to have any genotoxic activity in bacterial or mammalian cell in vitro mutagenic and transformation assays. High doses of Cholesterol were teratogenic in rats. Cholesterol has not been established as a promoter, cocarcinogen, or total carcinogen. Clinical studies to evaluate the safety of topically applied Cholesterol were restricted to products formulated with the ingredient. Most products were moisturizers containing 1.4% Cholesterol. The highest concentration of Cholesterol tested (6%) was evaluated in a modified prophetic test (110 subjects) and an RIPT (45 subjects); both assays had UVA and UVB exposure incorporated into the protocols. The Cholesterol-containing products were minimal to mild primary and cumulative skin irritants but not sensitizers or photosensitizers.

Use this, not that!

Products where you might find Cholesterol

Lord Jones Acid Mantle Repair Moisturizer With 250mg CBD and Ceramides; Skinfix Barrier+ Lipid-Boost Body Cream; BeautyBio The Quench Quadralipid Rapid Recovery Facial Moisturizer