Stearyl Glycyrrhetinate

The Basics On Stearyl Glycyrrhetinate

What is Stearyl Glycyrrhetinate?

The fatty acid form of the skin soothing glycyrrhetinic acid, which is derived from licorice.

What are other names for Stearyl Glycyrrhetinate?

3-HYDROXY-11-OXO- OCTADECYL ESTER OLEAN-12-EN-29-OIC ACID, OCTADECYL 3-HYDROXY-11-OXOOLEAN-12-EN-29-OATE, OCTADECYL ESTER OLEAN-12-EN-29-OIC ACID, 3-HYDROXY-11-OXO-, OCTADECYL GLYCYRRHETINATE, OLEAN-12-EN-29-OIC ACID, 3-HYDROXY-11-OXO-, OCTADECYL ESTER, and STEARYL GLYCYRRHETINATE

What is Stearyl Glycyrrhetinate used for?

Compared to glycyrrhetinic acid, Stearyl Glycyrrhetinate has a low melting point. In cosmetic and pharma industries, it has a long history of use; it has been used to improve anti-viral effects, reduce inflammation, prevent allergies, cleanse the skin, provide skin whitening and to assist with sun protection.

How Stearyl Glycyrrhetinate is classified

Skin-Soothing, Plant Extracts

Recommendations for using Stearyl Glycyrrhetinate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Stearyl Glycyrrhetinate During Pregnancy

What we know about using Stearyl Glycyrrhetinate while pregnant or breastfeeding

Limited information available.

FDRL (1971b) studied the developmental toxicity potential of Ammonium Glycyrrhizate in four species of mammals. Pregnant CD-1 outbred mice received 0, 27, 90, 300, or 1000 mg/kg/day Ammonium Glycyrrhizate by oral gavage on gestation days 6 through 15 (n = 19 to 21 pregnant dams/dose group). The fetuses were removed by caesarian section on gestation day 17 and examined. There was no effect on maternal or fetal survival and no remarkable observation upon visceral and skeletal examinations of the fetuses. Pregnant Wistar rats received 0, 27, 90, 300, or 1000 mg/kg/day Ammonium Glycyrrhizate by oral gavage on gestation days 6 through 15 (n = 21 to 22 pregnant dams/dose group). The fetuses were removed by caesarian section on gestation day 20 and examined. There was no effect on maternal or fetal survival and no remarkable observation upon visceral and skeletal examinations of the fetuses. Pregnant golden hamsters received 0, 27, 90, 300, or 1000 mg/kg/day Ammonium Glycyrrhizate by oral gavage on gestation days 6 through 10 (n = 21 to 23 pregnant dams/dose group). The fetuses were removed by caesarian section on gestation day 15 and examined. There was no effect on maternal or fetal survival. Aside from dose-dependent delayed cranial ossification, no remarkable observation upon visceral and skeletal examinations of the fetuses was noted. Pregnant Dutch-belted rabbits received 0, 27, 90, 300, or 1000 mg/kg/day Ammonium Glycyrrhizate by oral gavage on gestation days 6 through 18 (n = 10 to 12 pregnant dams/dose group). The fetuses were removed by caesarian section on gestation day 29 and examined. There was no effect on maternal or fetal survival and no remarkable observation upon visceral and skeletal examinations of the fetuses (FDRL 1971b). In the previously mentioned Monlux (1974) study where rats were fed Glycyrrhizate, exposure to up to 4% Ammonium Glycyrrhizate in utero did not cause any observed developmental defects. Mantovani et al. (1988) studied the teratogenicity of Ammonium Glycyrrhizate in Sprague-Dawley rats. Pregnant rats received drinking water containing 0, 10, 100, or 250 mg/ml Ammonium Glycyrrhizate on gestation days 7 through 17. The actual exposure levels, based on water consumption calculations, were 0, 21.33, 238.8, and 679.9 mg/kg/day, respectively. Dams were killed on gestation day 20. Dams and fetuses were examined. Water consumption was increased in dams of the 238.8 and 679.9 mg/kg/day groups. Fetuses exposed to Ammonium Glycyrrhizate did not have changes in the rate of external malformations, body weight, or degree of ossification, compared to controls. The incidence of external hemorrhages was increased in fetuses of the low- (21.33 mg/kg/day) and high- (679.9 mg/kg/day) dose groups (p < 0.01), but not in the middle- (238.8 mg/kg/day) dose group. Renal variants and ectopic kidneys were observed in fetuses of the lowest-dose group (p < 0.05). High-dose fetuses also had ectopic kidneys. Skeletal examinations revealed a dose-dependent increase in sternebral variants, significant (p < 0.01) in the middle- and high-dose groups. The lowest observed effect level in this study was 21.33 mg/kg/day. Itami et al. (1985) gave pregnant Wistar rats 0%, 0.08%, 0.4%, or 2% Disodium Glycyrrhizate mixed in feed on gestation days 0 through 20 (n = 8 to 11 pregnant dams/dose group). There was no treatment-related effect on any of the following parameters: number of corpora lutea, number of implants, number of live fetuses, number of intrauterine dead fetuses per litter, sex ratio, fetal body weights, placental weights, degree of ossification, live birth index, survival rate, and pup body weight gain up to 8 weeks postpartum. The authors concluded that Disodium Glycyrrhizate was not teratogenic in rats under the treatment conditions of this study.

General safety info about Stearyl Glycyrrhetinate from CIR

Glycyrrhetinic Acid and its salts and esters and Glycyrrhizic Acid and its salts and esters are cosmetic ingredients that function as flavoring agents or skin-conditioning agents—miscellaneous or both. These chemicals may be isolated from licorice plants. Glycyrrhetinc Acid is described as at least 98% pure, with 0.6% 24- OH-Glycyrrhetinic Acid, not more than 20 μg/g of heavy metals and not more than 2 μg/g of arsenic. Ammonium Glycyrrhizate has been found to be at least 98% pure and Dipotassium Glycyrrhizate has been found to be at least 95% pure. Glycyrrhetinic Acid is used in cosmetics at concentrations of up to 2%; Stearyl Glycyrrhetinate, up to 1%; Glycyrrhizic Acid, up to 0.1%; Ammonium Glycyrrhizate, up to 5%; Dipotassium Glycyrrhizate, up to 1%; and Potassium Glycyrretinate, up to 1%. Although Glycyrrhizic Acid is poorly absorbed by the intestinal tract, it may be hydrolyzed to Glycyrrhetinic Acid by a β-glucuronidase produced by intestinal bacteria. Glycyrrhetinic Acid and Glycyrrhizic Acid bind to rat and human albumin, but do not absorb well into tissues. Glycyrrhetinic Acid and Glycyrrhizic Acid and metabolites are mostly excreted in the bile, with very little excreted in urine. Dipotassium Glycyrrhizate was undetectable in the receptor chamber when tested for transepidermal permeation through pig skin. Glycyrrhizic Acid increased the dermal penetration of diclofenac sodium in rat skin. Dipotassium Glycyrrhizate increased the intestinal absorption of calcitonin in rats. In humans, Glycyrrhetinic Acid potentiated the effects of hydrocortisone in the skin. Moderate chronic or high acute exposure to Glycyrrhizic Acid, Ammonium Glycyrrhizate, and their metabolites have been demonstrated to cause transient systemic alterations, including increased potassium excretion, sodium and water retention, body weight gain, alkalosis, suppression of the renin-angiotensis-aldosterone system, hypertension, and muscular paralysis; possibly through inhibition of 11β-hydroxysteroid dehydrogenase-2 (11β-OHSD2) in the kidney. Glycyrrhetinic Acid and its derivatives block gap junction intracellular communication in a dose-dependent manner in Received 30 November 2006; accepted 5 March 2007. 1Reviewed by the Cosmetic Ingredient Review Expert Panel. Address correspondence to F. Alan Andersen, Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. animal and human cells, including epithelial cells, fibroblasts, osteoblasts, hepatocytes, and astrocytes; at high concentrations, it is cytotoxic. Glycyrrhetinic Acid and Glycyrrhizic Acid protect liver tissue from carbon tetrachloride. Glycyrrhizic Acid has been used to treat chronic hepatitis, inhibiting the penetration of the hepatitis A virus into hepatocytes. Glycyrrhetinic Acid and Glycyrrhizic Acid have anti-inflammatory effects in rats and mice. The acute intraperitoneal LD50 for Glycyrrhetinic Acid in mice was 308 mg/kg and the oral LD50 was >610 mg/kg. The oral LD50 in rats was reported to be 610 mg/kg. Higher LD50 values were generally reported for salts. Little short-term, subchronic, or chronic toxicity was seen in rats given ammonium, dipotassium, or disodium salts of Glycyrrhizic Acid. Glycyrrhetinic Acid was not irritating to shaved rabbit skin, but was considered slightly irritating in an in vitro test. Glycyrrhetinic Acid inhibited the mutagenic activity of benzo[a]pyrene and inhibited tumor initiation and promotion by other agents in mice. Glycyrrhizic Acid inhibited tumor initiation by another agent, but did not prevent tumor promotion in mice. Glycyrrhizic Acid delayed mortality in mice injected with Erlich ascites tumor cells, but did not reduce the mortality rate. Ammonium Glycyrrhizate was not genotoxic in in vivo and in vitro cytogenetics assays, the dominant lethal assay, an Ames assay, and heritable translocation tests, except for possible increase in dominant lethal mutations in rats given 2000 mg/kg day−1 in their diet. Disodium Glycyrrhizate was not carcinogenic in mice in a drinking water study at exposure levels up to 12.2 mg/kg day−1 for 96 weeks. Glycyrrhizate salts produced no reproductive or developmental toxicity in rats, mice, golden hamsters, or Dutch-belted rabbits, except for a dose-dependent increase (at 238.8 and 679.9 mg/kg day−1) in sternebral variants in a study using rats. Sedation, hypnosis, hypothermia, and respiratory depression were seen in mice given 1250 mg/kg Glycyrrhetinic Acid intraperitoneally. Rats fed a powdered diet containing up to 4% Ammonium Glycyrrhizate had no treatment related effects in motor function tests, but active avoidance was facilitated at 4%, unaffected at 3%, and depressed at 2%. In a study of 39 healthy volunteers, a no effect level of 2 mg/kg/day was determined for Glycyrrhizic Acid given orally for 8 weeks. Clinical tests in seven normal individuals given oral Ammonium Glycyrrhizate at 6 g/day for 3 days revealed reduced renal and thermal sweat excretion of Na+ and K+, but carbohydrate and protein metabolism were not affected. Glycyrrhetinic Acid at concentrations up to 6% was not a skin irritant or a sensitizer in clinical tests. Neither Glycyrrhizic Acid, Ammonium Glycyrrhizate,

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Products where you might find Stearyl Glycyrrhetinate

Biossance Squalane + Bamboo Deodorant; only 1 product listed