Copper Sulfate

The Basics On Copper Sulfate

What is Copper Sulfate?

Effective for soothing skin.

What are other names for Copper Sulfate?

V

What is Copper Sulfate used for?

Copper sulphate is associated with wound healing, while copper PCA is a salt that is a soothing, hydrating humectant and has some antimicrobial effects, making it great for winter-dry skin.

How Copper Sulfate is classified

Uncategorized

Recommendations for using Copper Sulfate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Copper Sulfate During Pregnancy

What we know about using Copper Sulfate while pregnant or breastfeeding

Limited information available.

Copper Sulfate The embryotoxicity/teratogenicity of copper sulfate was evaluated using 34 pregnant golden hamsters of the Cricetus auratus strain (24 test and 10 controls).139 A stock solution of 0.125 M copper sulfate (0.80 mg Cu+2/ml) in water was used. The following doses of the test solution were injected i.v. (injected volume never exceeded 1 ml/100 g body weight) on day 8 of gestation: 2.13 mg Cu/kg (16 hamsters), 4.25 mg Cu/kg (3 hamsters), 7.50 mg Cu/kg (3 hamsters), and 10.0 mg Cu/kg (2 hamsters). Control animals were injected with demineralized water. The animals were killed at day 4 or 5 post-injection. The highest dose administered (10 mg Cu/kg) was maternicidal. When compared to controls, dosing with copper sulfate caused an increase in embryonic resorptions in the remaining dose groups. The following malformations were observed in the 2.3 mg Cu/kg dose group (12 abnormal embryos): thoracic wall hernias, encephalocoeles, spina bifida, and microphthalmia. Exencephaly, hydrocephalus, abdominal hernia, and abnormal spinal curvature were observed in the 4.25 mg Cu/kg dose group (4 abnormal embryos). Histological examination of the thoracic anomalies indicated that the heart was herniated through the opening in the thoracic wall (ectopia cordis). Malformations were not reported for the 7.50 mg Cu/kg dose group. Copper sulfate was teratogenic as well as embryocidal in this study. Pregnant female CFLP female mice (6 to 8 weeks old) were injected i.v. with copper sulfate on gestation day 7 (7 mice), day 8 (12 mice), or day 9 (6 mice) and then examined on gestation day 10.140 Injection on day 7 induced embryolethality. The majority of surviving embryos of females injected on day 8 had anomalies of the neural tube and/or the heart. Injection on day 9 resulted in a very low incidence of anomalies. The most common malformations observed on day 10 involved failure of neural tube closure in the head region of the embryo and various types of anomalies of cardiac rotation and shape. When additional females injected on day 8 were examined on day 12, exencephaly was found in a high proportion of the fetuses examined. In an in vitro experiment, embryos from untreated females were explanted on day 9 and cultured in vitro with concentrations of copper sulfate of 5 x 10-6 M, 2.5 x 10-5 M, and 5 x 10-5 M. The lowest concentration had little obvious effect on neural tube closure. Retarded and anomalous embryonic development was noted at the intermediate dose, and the highest concentration resulted in neural tube and cardiac anomalies that were similar to those produced in vivo. The authors noted that the results of this study indicated that copper sulfate had a toxic effect on embryonic development. 28 Five pregnant, random-bred female Wistar rats (ages not stated) were dosed i.p. with aqueous copper sulfate (2 mg Cu/kg; dose volume = 0.1 ml/100g) on gestation day 8.141 The control group of 5 rats received deionized water. The animals were killed on gestation day 19. Dosing with the test material had no significant effect on the incidence of fetal resorption when compared to the control group. The test material also induced a higher incidence of the following fetal abnormalities, but the differences were not statistically significant: skeletal retardation, the absence of or delayed ossification of vertebrae, foreshortening of the ribs, and ectrodactyly. Groups of 20 Fischer 344/N rats (10 males, 10 females/group; 6 weeks old) received copper sulfate at the following concentrations in dosed feed for 92 days: 500 ppm, 1,000 ppm, 2,000 ppm, 4,000 ppm, and 8,000 ppm.84 The control group received drinking water without the test material. Complete necropsy was performed on all animals that died early and at the end of the study (all test and control animals included). Complete histopathologic examination involved the following groups: all control animals, all animals that died early, all animals in the highest dose group with at least 60% survivors, and all animals in higher dose groups. Groups of 20 B6C3F1 mice (10 males, 10 females/group; 6 weeks old) received copper sulfate at the following concentrations in dosed feed for 92 days: 1,000 ppm, 2,000 ppm, 4,000 ppm, 8,000 ppm, and 16,000 ppm for 92 days. The control group received drinking water without the test material. Complete necropsies and histopathologic examinations were performed as stated for rats in the preceding experiment. Sperm morphology and vaginal cytology evaluations were performed on rats and mice. The control and 3 highest exposure groups for mice and rats were evaluated. Epididymal sperm motility was evaluated at necropsy and vaginal cytology was evaluated in animals during the week preceding necropsy. Copper sulfate produced no adverse effects on any of the reproductive parameters measured in rats or mice of either sex. Other study results are included in the Repeated Dose Toxicity – Oral section of this report. The structural integrity of rabbit spermatozoa after exposure to copper sulfate was evaluated in an in vitro study.142 At least 500 spermatozoa per sample were evaluated, and the concentration of copper sulfate in the incubation medium ranged from 3.57 to 4.85 µg copper sulfate/ml. When compared to the control culture, decreased motility of spermatozoa was noted over the range of test concentrations. At time 0, the difference was statistically significant at concentrations ranging from 3.70 to 4.85 µg copper sulfate/ml. After 48 h, almost all spermatozoa were dead, i.e., no motility at all concentrations. When compared to the control culture (30.60% abnormal spermatozoa), the total percentage of morphologically abnormal spermatozoa was significantly higher (46.20%; P < 0.05) at the highest copper sulfate concentration. Two groups of 12 NMRI female mice (6 weeks old) were dosed orally with copper sulfate (0.2 cc, by gavage) at doses of 100 mg/kg and 200 mg/kg, respectively, once daily for 35 consecutive days.143 Six control rats were dosed with saline (0.2 cc) according to the same procedure. The animals from each experimental group were killed at 14 and 35 days, and the ovaries were removed for light and electron microscopic examination. Only the number of antral follicles was decreased on day 14, when compared to the control group (P = 0.043). The higher copper sulfate dose (200 mg/kg) or a longer consumption period significantly reduced different classes of follicles and corpora lutea. The following mild ultrastructural cellular damage was observed on day 14, after dosing with 100 mg/kg: decrease in zona pellucida thickness, limited vacuolated areas, and nuclear envelop dilation. The higher dose (200 mg/kg) or longer copper sulfate administration caused more detrimental effects, described as follows: more vacuolated areas, presence of secondary lysosomes, irregularity in cell shape and segmented nuclei with condensed and marginated chromatin, and more enlarged and damaged mitochondria.

General safety info about Copper Sulfate from CIR

No report found.

Use this, not that!

Products where you might find Copper Sulfate

The Ordinary “Buffet” + Copper Peptides 1%; Christophe Robin Shade Variation Mask – Chic Copper; Dr Roebuck’s Ningaloo Copper Peptide Firming Serum