Coffea Arabica (Coffee) Fruit Extract

The Basics On Coffea Arabica (Coffee) Fruit Extract

What is Coffea Arabica (Coffee) Fruit Extract?

Coffee fruit extract is an excellent antioxidant when applied to skin, or consumed orally.

What are other names for Coffea Arabica (Coffee) Fruit Extract?

COFFEA ARABICA FRUIT EXTRACT

What is Coffea Arabica (Coffee) Fruit Extract used for?

Among other antioxidants, coffee is a rich source of ferulic acid. On skin, the extract has been shown to reduce the occurrence of destructive enzymes that lead to signs of aging as well as help visibly repair signs of sun damage.

How Coffea Arabica (Coffee) Fruit Extract is classified

Antioxidants, Plant Extracts

Recommendations for using Coffea Arabica (Coffee) Fruit Extract during pregnancy and breastfeeding

Limited data suggests no known risk

 

Coffea Arabica (Coffee) Fruit Extract During Pregnancy

What we know about using Coffea Arabica (Coffee) Fruit Extract while pregnant or breastfeeding

Limited information available.

Gross malformations and reproductive effects were reported in studies involving Caffeine, and teratogenic, fetotoxic, and maternal-toxic effects were reported in studies examining the effects of Theophylline and Theobromine in mice and rats.6,9 However, data from OECD SIDS suggests that the usual range of human exposure to Caffeine through food and beverage intake is far less than the threshold dose that would result in developmental, teratogenic, or reproductive effects.5 Studies were performed evaluating the developmental toxicity of Caffeine in mice. Mice dosed with 350 mg/kg (gestation days 8-19) and up to 39 mg/kg/d displayed no dose-related effects.5,37 In different studies, mice displayed reduced maternal body weight gain (100-400 mg/kg/d Caffeine; gestation days (g.d.) 6-15) a reduction of live male pups/litter, female body weight, and adjusted seminal vesicle weight (up to 88 mg/kg/d; 21-35 weeks).5 Multiple reproductive toxicity studies were performed using rats. Dose-dependent maternal weight gain decreases were reported when rats were dosed with 10-40 mg/kg/d (g.d. 1-20), 40-80 mg/kg/d (g.d. (1-19), 10-100 mg/kg/d (g.d. 6-20), 100 mg/kg/d (g.d. 7-19, 7-16, 16-19 or day 19), and 70-2000 ppm (g.d. 0-20).5 In a study where Osborne-Mendel rats were treated with up to 125 mg/kg via gavage on gestation days 0-19, 6/61 females died at the highest dose level. At the 80 mg/kg dose level, 2 litters were resorbed, and at the 125 mg/kg dose level, 4 litters were resorbed. Resorption was also noted at doses of 1500 and 2000 ppm in a different study involving rats given Caffeine in drinking water on days 0-20 of gestation. A 23% sperm radius decrease, as well as a decrease in sperm motility and velocity was observed in rats given 25 mg/kg Caffeine via oral gavage. When rats were dosed with up to 320 mg/kg/d on days 6-16 of gestation, a maternal toxicity NOAEL of 56 mg/kg bw and a teratogenicity NOAEL of 100 mg/kg bw was established. No teratogenic effects were observed when rabbits were given up to 125 mg/kg of Caffeine via gavage on gestation days 6- 16.5 When 40 pregnant monkeys were given Caffeine in drinking water eight weeks before pregnancy to several months after pregnancy, a dose-related increase in stillbirths, decreased maternal weight, and miscarriages were present. In a study where rats were given up to 99 mg/kg bw/d during gestation days 6-19, no maternal toxicity was reported, but a slight decrease in fetal body weight as well as an increase in skeletal variation frequency was apparent. 9 When rats were given 500 mg/kg bw/d for 3 or 5 days, interference of germ cell kinetics was observed, but spermatagonia was not present. Rabbits given up to 63 mg/kg bw via feed displayed little to no maternal toxicity. In a different study, rabbits were given up to 200 mg/kg bw Theobromine via gavage on gestation days 6-29. At the 200 mg/kg dose level, 40% of the dams died, but little to no maternal toxicity was reported in rabbits given 25-125 mg/kg. Mice given 0.2% Theophylline on gestation days 6-15 via drinking water displayed an increased percentage of resorptions/litter and a reduced lumber of live fetuses.35 Dose-related decreases in the number of live pups/litter was also reported in a different study in which mice were given 0.3% Theophylline in feed for one week before mating and during 13 weeks of cohabitation.9 A statistically significant decrease in testicular weight was observed at the 300 mg/kg bw dose level in mice dosed for 13 weeks via gavage or diet. However, no effects were reported at the 150 mg/kg bw dose level. Decreases in litter size and fetal weight was noted in rats dosed with 0.4% Theophylline on gestation days 6-15.35

General safety info about Coffea Arabica (Coffee) Fruit Extract from CIR

No report found.

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Products where you might find Coffea Arabica (Coffee) Fruit Extract

Jouer Cosmetics Essential High Coverage Liquid Concealer; Glow Recipe Avocado Melt Retinol Eye Sleeping Mask; COOLA Sunless Tan Express Sculpting Mousse