Coenzyme Q10

The Basics On Coenzyme Q10

What is Coenzyme Q10?

Also known as ubiquinone, it is a vitamin-like, fat-soluble substance.

What are other names for Coenzyme Q10?

2,5-CYCLOHEXADIENE-1,4-DIONE, 2-(3,7,11,15,19,23,27,31,35,39-DECAMETHYL-2,6,10,14,18,22,26,30,34,38-, 2,5-CYCLOHEXADIENE-1,4-DIONE, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-DECAMETHYL-2,6,10,14,18,22,26,30,34,38-TETRACONTADECAENYL]-5,6-DIMETHOXY-3-METHYL-, 2-(3,7,11,15,19,23,27,31,35,39-DECAMETHYL-2,6,10,14,18,22,26,30,34,38- 2,5-CYCLOHEXADIENE-1,4-DIONE, 2-(3,7,11,15,19,23,27,31,35,39-DECAMETHYL-2,6,10,14,18,22,26,30,34,38-TETRACONTADECAENYL)-5,6-DIMETHOXY-3-METHYL-2,5-CYCLOHEXADIENE-1,4-DIONE, COENZYME Q10, TETRACONTADECAENYL)-5,6-DIMETHOXY-3-METHYL-,, UBIQUINONE, UBIQUINONE 10, UBIQUINONE 50, and UBIQUINONE Q10

What is Coenzyme Q10 used for?

CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. Consequently, topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in the skin in vivo2. CoQ10 can also play a role in making your skin look younger. CoQ10 levels decrease as people get older. Most women over thirty already have below optimum levels of CoQ10 in their skin. This reduction in CoQ10 levels results in a reduced ability of the skin to produce collagen and elastin. Collagen is the protein that makes your skin firm, while elastin is a protein that gives your skin flexibility. This loss of collagen and elastin is what causes your skin to wrinkle and sag. CoQ10 also helps the skin by acting as a strong antioxidant. It helps to neutralize the harmful free radicals that are one of the major causes of aging. With the age-related decline in CoQ10, your skin becomes more prone to damage by free radicals. Using topical anti-aging creams that contain CoQ10 can effectively help fight the signs of aging. The CoQ10 in the treatment can penetrate deeply to provide antioxidants and help create collagen and elastin.

How Coenzyme Q10 is classified

Skin-Soothing, Antioxidants

Recommendations for using Coenzyme Q10 during pregnancy and breastfeeding

Limited data suggests no known risk

 

Coenzyme Q10 During Pregnancy

What we know about using Coenzyme Q10 while pregnant or breastfeeding

Limited information available.

No adverse effects on fertitily or reproductive performance were observed in a study in which male and female Wistar rats were dosed orally with up to 500 mg/kg bw Hydroxydecyl Ubiquinone prior to mating, during gestation, and until day 22 post-partum. 45 In several other studies, no statistically significant adverse effects upon reproductive performance or fetal development were seen in rats dosed at up to 1000 mg/kg/d Hydroxydecyl Ubiquinone, although a higher incidence of postimplanation loss was reported in some studies. 3,4 The NOAELs, based on body surface area comparisons, were determined to be up to 1000 mg/kg/d for embryofetal development, and 500 mg/kg/d and 1000 mg/kg/d, for male and female fertility, respectively. 4 Rabbits, dosed at up to 150 mg/kg/d Hydroxydecyl Ubiquinone and observed for teratological abnormalities, displayed chromaturia in the highest dosage group. 3 In Japanese rabbits dosed at up to 500 mg/kg/d Hydroxydecyl Ubiquinone, one abortion was observed in the highest dosage group, but was not considered significant due to the spontaneous abortion rate in the animal strain; no statistically significant embryofetal differences were reported between controls and treated groups.4 No treatment-related changes were observed in the F1 generation, or in the dams, of rats dosed at up to 500 mg/kg/d Hydroxydecyl Ubiquinone. 3,4 The NOAEL for rat pup development was determined to be 500 mg/kg/d Hydroxydecyl Ubiquinone. 4 Treatment with Ubiquinone had no effect on fetal death, weight, or postnatal toxicity in primigravid mice (strain and number not specified) dosed at up to 600 mg/kg/d, from day 7 to day 13 of gestation. 29 Groups of 10 male mice were given up to 10,000 mg/kg bw Ubiquinone, via gavage, for 5 d to test for defects in sperm morphology.47 No significant differences were found in the incidence of sperm abnormalities between Ubiquinone-treated mice and the negative controls (treated with corn oil). Except for an increase in seminiferous epithelium heights, no biochemic, histologic, or morphologic differences were observed between 8 male Wistar rats dosed at 10 mg/kg bw/d Ubiquinone for 14 d and negative control and vehicle control groups.49 Treatment with Ubiquinone had no effect on fetal death, weight, or postnatal activity in primigravid rats dosed at up to 600 mg/kg/d, from day 9 to day 15 of gestation. 29

General safety info about Coenzyme Q10 from CIR

No report found.

Use this, not that!

Products where you might find Coenzyme Q10

DHC Coenzyme Q10 Cream, SKIN INC Supplement Bar Coenzyme Q10 Serum, DHC Coenzyme Q10 Cream Mini; Indie Lee CoQ-10 Toner, Estee Lauder NightWear Plus Anti-Oxidant Night Detox Creme, Dr. Jart+ Dermask Intra Jet Wrinkless Solution