Phytonadione

The Basics On Phytonadione

What is Phytonadione?

One form of vitamin K.

What are other names for Phytonadione?

1,4-NAPHTHALENEDIONE, 2-METHYL-3-(3,7,11,15-TETRAMETHYL-2-HEXADECENYL)-, 1,4-NAPHTHALENEDIONE, 2-METHYL-3-[(2E,7R,11R)-3,7,11,15-TETRAMETHYL-2-HEXADECENYL]-, 1,4NAPHTHALENEDIONE, 2METHYL3(3,7,11,15TETRAMETHYL2HEXADECENYL), [R[R*,R*(E)]], 2-METHYL-3-(3,7,11,15-TETRAMETHYL-2-HEXADECENYL)- 1,4-NAPHTHALENEDIONE, 2-METHYL-3-(3,7,11,15-TETRAMETHYL-2-HEXADECENYL)-1,4-NAPHTHALENEDIONE, PHYLLOQUINONE, PHYTOMENADIONE, and PHYTONADIONE

What is Phytonadione used for?

Phytonadione is a man-made form of vitamin K, which occurs naturally in the body. Phytonadione is used to treat vitamin K deficiency, and to treat certain bleeding or blood-clotting problems caused by other medicines or medical conditions. Phytonadione may also be used for purposes not listed in this medication guide.

How Phytonadione is classified

Vitamins

Recommendations for using Phytonadione during pregnancy and breastfeeding

Limited data suggests no known risk

 

Phytonadione During Pregnancy

What we know about using Phytonadione while pregnant or breastfeeding

Limited information available.

No adverse effects on fertitily or reproductive performance were observed in a study in which male and female Wistar rats were dosed orally with up to 500 mg/kg bw Hydroxydecyl Ubiquinone prior to mating, during gestation, and until day 22 post-partum. 45 In several other studies, no statistically significant adverse effects upon reproductive performance or fetal development were seen in rats dosed at up to 1000 mg/kg/d Hydroxydecyl Ubiquinone, although a higher incidence of postimplanation loss was reported in some studies. 3,4 The NOAELs, based on body surface area comparisons, were determined to be up to 1000 mg/kg/d for embryofetal development, and 500 mg/kg/d and 1000 mg/kg/d, for male and female fertility, respectively. 4 Rabbits, dosed at up to 150 mg/kg/d Hydroxydecyl Ubiquinone and observed for teratological abnormalities, displayed chromaturia in the highest dosage group. 3 In Japanese rabbits dosed at up to 500 mg/kg/d Hydroxydecyl Ubiquinone, one abortion was observed in the highest dosage group, but was not considered significant due to the spontaneous abortion rate in the animal strain; no statistically significant embryofetal differences were reported between controls and treated groups.4 No treatment-related changes were observed in the F1 generation, or in the dams, of rats dosed at up to 500 mg/kg/d Hydroxydecyl Ubiquinone. 3,4 The NOAEL for rat pup development was determined to be 500 mg/kg/d Hydroxydecyl Ubiquinone. 4 Treatment with Ubiquinone had no effect on fetal death, weight, or postnatal toxicity in primigravid mice (strain and number not specified) dosed at up to 600 mg/kg/d, from day 7 to day 13 of gestation. 29 Groups of 10 male mice were given up to 10,000 mg/kg bw Ubiquinone, via gavage, for 5 d to test for defects in sperm morphology.47 No significant differences were found in the incidence of sperm abnormalities between Ubiquinone-treated mice and the negative controls (treated with corn oil). Except for an increase in seminiferous epithelium heights, no biochemic, histologic, or morphologic differences were observed between 8 male Wistar rats dosed at 10 mg/kg bw/d Ubiquinone for 14 d and negative control and vehicle control groups.49 Treatment with Ubiquinone had no effect on fetal death, weight, or postnatal activity in primigravid rats dosed at up to 600 mg/kg/d, from day 9 to day 15 of gestation. 29

General safety info about Phytonadione from CIR

No report found.

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Products where you might find Phytonadione

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