Triethylhexanoin

The Basics On Triethylhexanoin

What is Triethylhexanoin?

Triethylhexanoin is a synthetic mixture of glycerin and a fatty acid that functions as a solvent, occlusive, and skin-conditioning ingredient.

What are other names for Triethylhexanoin?

1,2,3-PROPANETRIYL ESTER 2-ETHYLHEXANOIC ACID, 1,2,3-PROPANETRIYL ESTER HEXANOIC ACID, 2-ETHYL-, 2-ETHYL- 1,2,3-PROPANETRIYL ESTER HEXANOIC ACID, 2-ETHYLHEXANOIC ACID, 1,2,3-PROPANETRIYL ESTER, GLYCERYL TRI(2-ETHYLHEXANOATE), HEXANOIC ACID, 2-ETHYL-, 1,2,3-PROPANETRIYL ESTER, PROPANE-1,2,3-TRIYL 2-ETHYLHEXANOATE, and TRIETHYLHEXANOIN

What is Triethylhexanoin used for?

Triethylhexanoin is a glyceryl triester or triglyceride. It is used as a skin conditioning agent, emollient, anti-static agent, solvent in personal care products such as make-up, creams and lotions, deodorants, skin care and skin cleansing products.

How Triethylhexanoin is classified

Emollients

Recommendations for using Triethylhexanoin during pregnancy and breastfeeding

Limited data suggests no known risk

 

Triethylhexanoin During Pregnancy

What we know about using Triethylhexanoin while pregnant or breastfeeding

Limited information available.

Tricaprylin was not teratogenic in mice or rats when administered orally 4 In another study on reproductive effects, Tricaprylin was effective in producing fusion of the endometrial epithelium (symplasma formation) and decidualization of the stroma in pseudopregnant New Zealand white rabbits. The oral administration of Trioctanoin to mice did not result in any significant differences in indices of potential developmental toxicity (i.e., litter size, birth weight, and neonatal growth and survival to postnatal day 3) between test and control groups. Test results for 291 fetuses from various strains of mice injected intraperitoneally with Trioctanoin (vehicle control) in a teratogenicity study indicated various kinds of eye abnormalities in 6.2% of the fetuses. In a reproduction study, young adult male and female rats were fed a balanced diet containing 19.6% of a triglyceride of 75% caprylic and 25% capric acid for three weeks before mating.5 Litter size and birth weight of the test animals were similar to those of rats on conventional or low fat diets, but mortality during lactation was somewhat higher, and there was less weight gain due to a smaller volume of milk secreted. After weaning, the F1 generation was fed as the F0 generation had been and showed a weight gain comparable to that of control rats. Tricaprylin In a study evaluating the developmental toxicity of trichloroacetonitrile in which Tricaprylin was used as a vehicle, a possibly biologically significant effect (increased resorptions, reduced fetal weight, and anomalies) was observed in the Tricaprylin control group when compared to the water control group.39 Therefore, the developmental toxicity of trichloroacetonitrile was reexamined using Tricaprylin and corn oil as vehicles. Groups of 20 gravid Long-Evans rats were dosed by Distributed for comment only — do not cite or quote gavage on days 6-18 of gestation with 15 mg/kg/day trichloroacetonitrile in Tricaprylin and 15-75 mg/kg/day trichloroacetonitrile in corn oil; vehicle control groups were dosed with Tricaprylin, corn oil only, and water. The dosing volume was 10 ml/kg. All dams were killed on day 20 of gestation. Statistically significant difference in some parameters was observed in the Tricaprylin control group compared to the water and/or corn oil control groups. There was a statistically significant increase in the percent implantation loss in the Tricaprylin group as compared to both the water and corn oil controls, and the total implants/litter was statistically significantly less when compared to the corn oil, but not the water, control group. Also, there were statistically significant decreases in fetal body weights and crown-rump length in the Tricaprylin control group as compared to the water and corn oil control groups. There was no difference in the incidence of fetal anomalies among the three control groups. In the dams, the maternal average kidney weight was statistically significantly increased in the Tricaprylin controls when compared to the water and corn oil controls; no effect on liver or spleen weight was reported. The study authors postulated that the differences observed between the Tricaprylin group and the other two control groups may be attributable to potential changes in nutritional status. Dams of the Tricaprylin group gained significantly less weight than those of the corn oil group during days 15-18 of gestation. However, food and water consumption were not monitored. The stud y authors also stated that the differences in reproductive parameters could be due to normal variation for LongEvans rats. Additionally, the developmental toxicity of trichloroacetonitrile appeared to be vehicle-dependent; developmental effects caused by trichloroacetonitrile were seen at higher doses when administered in corn oil compared to those seen when Tricaprylin was used as the vehicle. The study authors suggested that trichloroacetonitrile and Tricaprylin ‚Äúappear to interact in some way to potentiate effects of the cardiovascular system.‚Äù

General safety info about Triethylhexanoin from CIR

No report found.

Use this, not that!

Products where you might find Triethylhexanoin

N/A