The Basics On Caffeic Acid
What is Caffeic Acid?
Organic compound that is classified as a hydroxycinnamic acid and has antioxidant properties.
What are other names for Caffeic Acid?
2-PROPENOIC ACID, 3-(3,4-DIHYDROXYPHENYL)-, 2PROPENOIC ACID, 3(3,4DIHYDROXYPHENYL), 3,4-DIHYDROXYBENZENEACRYLIC ACID, 3,4-DIHYDROXYCINNAMIC ACID, 3-(3,4-DIHYDROXYPHENYL)- 2-PROPENOIC ACID, 3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID, and CAFFEIC ACID
What is Caffeic Acid used for?
Caffeic Acid is a hydroxycinnamic acid derivative and polyphenol, with potential antioxidant, anti-inflammatory, and antineoplastic activities. Upon administration, caffeic acid acts as an antioxidant and prevents oxidative stress, thereby preventing DNA damage induced by free radicals. A study using a maximum dose of caffeic acid (l0μg/mL) normalized the UVB induced cellular changes indicating the photoprotective effect of caffeic acid in irradiated lymphocytes5. The results of another study suggested that this caffeic acid could act as a potent chemopreventive agent against skin cancer6. Caffeic acid has been shown to have good penetration capabilities for the epidermis and dermis upon topical application7. Conclusions
How Caffeic Acid is classified
Antioxidants
Recommendations for using Caffeic Acid during pregnancy and breastfeeding
Limited data suggests no known risk
Caffeic Acid During Pregnancy
What we know about using Caffeic Acid while pregnant or breastfeeding
Limited information available.
N/A
General safety info about Caffeic Acid from CIR
No report found.
Use this, not that!
Products where you might find Caffeic Acid
Lancer Skincare The Method: Body Nourish with Hylaplex and Glycolic Acid 10%; Paula’s Choice RESIST Daily Smoothing Treatment with 5% Alpha Hydroxy Acid; Naturopathica Chlorophyll & Salicylic Acid Spot Treatment; The Ordinary 100% Organic Cold-Pressed Moroccan Argan Oil; only 1 product listed
List of References
General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
1. Baumann L. Caffeic Acid. In: Cosmeceuticals and Cosmetic Ingredients. McGraw-Hill Education; 2007:166. 2. Centini M, Rossato M, Sega A, Buonocore A, Stefanoni S, Anselmi C. New multifunctional surfactants from natural phenolic acids. J Agric Food Chem. 2012;60(1):74-80. [PubMed] 3. Tinikul R, Chenprakhon P, Maenpuen S, Chaiyen P. Biotransformation of Plant-Derived Phenolic Acids. Biotechnol J. 2018;13(6):e1700632. [PubMed] 4. Wang W, Guo J, Zhang J, Peng J, Liu T, Xin Z. Isolation, identification and antioxidant activity of bound phenolic compounds present in rice bran. Food Chem. 2015;171:40-49. [PubMed] 5. Prasad N, Jeyanthimala K, Ramachandran S. Caffeic acid modulates ultraviolet radiation-B induced oxidative damage in human blood lymphocytes. J Photochem Photobiol B. 2009;95(3):196-203. [PubMed] 6. Kang N, Lee K, Shin B, et al. Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis. 2009;30(2):321-330. [PubMed] 7. Zilius M, Ramanauskienƒó K, Briedis V. Release of propolis phenolic acids from semisolid formulations and their penetration into the human skin in vitro. Evid Based Complement Alternat Med. 2013;2013:958717. [PubMed] Related Articles: Glossary: Coumaric acid Glossary: Vanillic acid Glossary: Cinnamic acid Glossary: Polyphenols
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
