Propylene Glycol

The Basics On Propylene Glycol

What is Propylene Glycol?

Along with other glycols and glycerol, propylene glycol is a humectant (hydrating) and delivery ingredient.

What are other names for Propylene Glycol?

1,2-DIHYDROXYPROPANE, 1,2-PROPANEDIOL, 2-HYDROXYPROPANOL, METHYLETHYL GLYCOL, PROPANE-1,2-DIOL, and PROPYLENE GLYCOL

What is Propylene Glycol used for?

Along with other glycols and glycerol, propylene glycol is a humectant (hydrating) and delivery ingredient used in cosmetics. In cosmetics, propylene glycol is used in small amounts to keep products from melting in high heat or from freezing. … It also helps active ingredients penetrate skin.

How Propylene Glycol is classified

Texture Enhancer

Recommendations for using Propylene Glycol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Propylene Glycol During Pregnancy

What we know about using Propylene Glycol while pregnant or breastfeeding

Limited information available.

Not likely to be a any toxicant in humans. In studies reported in the 1994 assessment1 and currently, PG did not have any adverse reproductive or developmental effects when evaluated in mice at doses of ≤5.0% PG, rats at doses of ≤1600 mg/kg PG, rabbits at doses of ≤1230 mg/kg PG, or hamsters at doses of ≤1550 mg/kg PG. Propylene Glycol The reproductive and developmental effects of PG were evaluated using mice, rats, rabbits, and hamsters.32 Groups of 25 or 28 female albino CD-1 outbred mice were mated and 22, 22, 22, 20, and 23 gravid mice were dosed by oral intubation with 0.0, 16.0, 74.3, 345.0, and 1600.0 mg/kg aq. PG on days 6-15 of gestation. Groups of 25-28 female albino Wistar rats were mated and 22, 23, 22, 20, and 24 were dosed as above, respectively. Positive control groups of 23 mice and 21 rats were given 150.0 or 250.0 mg/kg aspirin, respectively. Body weights were recorded at various intervals and general observations were made daily. Caesarian sections were performed on days 17 and 20 for all mice and rats, respectively. All fetuses were examined macroscopically for visceral or skeletal defects. Administration of PG did not affect maternal or fetal survival in mice or rats, and there were no statistically significant differences in fetal anomalies between test and negative control groups in mice or rats. Groups of 11, 11, 12, 14, and 13 gravid female Dutch-belted rabbits were dosed by oral intubation with 0, 12.3, 57.1, 267.0, or 1230.0 mg/kg aq. PG on days 6-18 of gestation. A positive control group of 10 gravid rabbits was given 2.5 mg/kg 6-aminonicotinamide. Body weights were recorded at various intervals and general observations were made daily. Caesarian sections were performed on day 29. All fetuses were examined macroscopically and kept for 24 h to evaluate survival. The pups were then examined viscerally and for skeletal defects. Administration of PG did not affect maternal or fetal survival, and there were no statistically significant differences in fetal anomalies between test and negative control group. Groups of 24-27 female golden hamsters were mated and 21, 24, 25, 22, and 22 gravid hamsters were dosed by oral intubation with 0.0, 15.5, 72.0, 334.5, and 1550.0 mg/kg aq. PG on days 6-10 of gestation. Positive controls were given 250.0 mg/kg aspirin. Body weights were recorded at various intervals and general observations were made daily. Caesarian sections were performed on day 14. All fetuses were examined macroscopically and for visceral or skeletal defects. Administration of PG did not affect maternal or fetal survival, and there were no statistically significant differences in fetal anomalies between test and negative control groups. PG was used as a vehicle in a reproductive and behavioral development study. 33 It was administered to 15 gravid Sprague-Dawley rats orally by gavage on days 7-18 of gestation at a volume of 2 ml/kg. PG did not have any effects on reproductive or behavioral development parameters.

General safety info about Propylene Glycol from CIR

Propylene Glycol is an aliphatic alcohol widely used in cosmetics that functions as a skin conditioning agent, viscosity decreasing agent, solvent, and fragrance ingredient. Polypropylene glycols, including PPG-3, PPG-7, PPG-9, PPG12, PPG-13, PPG-15, PPG-16, PPG-17, PPG-20, PPG-26, PPG-30, PPG-33, PPG-34, PPG-51, PPG-52, and PPG-69, have far fewer uses than propylene glycol and function primarily as skin conditioning agents, with some solvent use. Tripropylene glycol functions as a humectant, antioxidant, and emulsion stabilizer. The majority of the safety and toxicity information is limited to propylene glycol. The Expert Panel determined that the available information would be used to support the safety of all the polypropylene glycols as well as tripropylene glycol. Propylene glycol is generally non-toxic and is non-carcinogenic. A wide range of genotoxicity studies were negative. Clinical studies demonstrated an absence of dermal sensitization at use concentrations, although concerns about irritation remained. The Expert Panel concluded that propylene glycol, the polypropylene glycols, and tripropylene glycol are safe as used in cosmetic formulations when formulated to be nonirritating.

Use this, not that!

Products where you might find Propylene Glycol

Sol de Janeiro Brazilian Bum Bum Cream;Sol de Janeiro Mini Brazilian Bum Bum Cream;Dr. Jart+ Cicapair Tiger Grass Color Correcting Treatment SPF 30;Sol de Janeiro Brazilian 4 Play Moisturizing Shower Cream-Gel;Dr. Jart+ Sheet Masks