Tribehenin

The Basics On Tribehenin

What is Tribehenin?

Also known as glyceryl tribehenate, a skin-conditioning agent that is a mixture of glycerin and behenic acid.

What are other names for Tribehenin?

1,2,3-PROPANETRIYL ESTER BEHENIC ACID, 1,2,3-PROPANETRIYL ESTER DOCOSANOIC ACID, 1,2,3-PROPENETRIOL TRIDOCOSANOATE, BEHENIC ACID, 1,2,3-PROPANETRIYL ESTER, DOCOSANOIC ACID, 1,2,3-PROPANETRIYL ESTER, DOCOSANOIC ACID, 1,2,3PROPANETRIYL ESTER, GLYCERYL TRIBEHENATE, PROPANE-1,2,3-TRIYL TRIDOCOSANOATE, and TRIBEHENIN

What is Tribehenin used for?

How Tribehenin is classified

Thickeners/Emulsifiers, Skin-Replenishing, Emollients

Recommendations for using Tribehenin during pregnancy and breastfeeding

Limited data suggests no known risk

 

Tribehenin During Pregnancy

What we know about using Tribehenin while pregnant or breastfeeding

Limited information available.

Tricaprylin was not teratogenic in mice or rats when administered orally 4 In another study on reproductive effects, Tricaprylin was effective in producing fusion of the endometrial epithelium (symplasma formation) and decidualization of the stroma in pseudopregnant New Zealand white rabbits. The oral administration of Triethylhexanoin [Trioctanoin] to mice did not result in any significant differences in indices of potential developmental toxicity (i.e., litter size, birth weight, and neonatal growth and survival to postnatal day 3) between test and control groups. Test results for 291 fetuses from various strains of mice injected intraperitoneally with Triethylhexanoin [Trioctanoin] (vehicle control) in a teratogenicity study indicated various kinds of eye abnormalities in 6.2% of the fetuses. In a reproduction study, young adult male and female rats were fed a balanced diet containing 19.6% of a triglyceride of 75% caprylic and 25% capric acid for three weeks before mating.5 Litter size and birth weight of the test animals were similar to those of rats on conventional or low fat diets, but mortality during lactation was somewhat higher, and there was less weight gain due to a smaller volume of milk secreted. After weaning, the F1 generation was fed as the F0 generation had been and showed a weight gain comparable to that of control rats. Tricaprylin In a study evaluating the developmental toxicity of trichloroacetonitrile in which Tricaprylin was used as a vehicle, a possibly biologically significant effect (increased resorptions, reduced fetal weight, and anomalies) was observed in the Tricaprylin control group when compared to the water control group.40 Therefore, the developmental toxicity of trichloroacetonitrile was reexamined using Tricaprylin and corn oil as vehicles. Groups of 20 gravid Long-Evans rats were dosed by gavage on days 6-18 of gestation with 15 mg/kg/day trichloroacetonitrile in Tricaprylin and 15-75 mg/kg/day trichloroacetonitrile in corn oil; vehicle control groups were dosed with Tricaprylin, corn oil only, and water. The dosing volume was 10 ml/kg. All dams were killed on day 20 of gestation. Statistically significant difference in some parameters was observed in the Tricaprylin control group compared to the water and/or corn oil control groups. There was a statistically significant increase in the percent implantation loss in the Tricaprylin (only) group as compared to both the water and corn oil controls, and the total implants/litter was statistically significantly less when compared to the corn oil, but not the water, control group. Also, there were statistically significant decreases in fetal body weights and crown-rump length in the Tricaprylin control group as compared to the water and corn oil control groups. There was no statistically significant difference in the incidence of fetal anomalies among the three control groups. In the dams, the maternal average kidney weight was statistically significantly increased in the Tricaprylin controls when compared to the water and corn oil controls; no effect on liver or spleen weight was reported. The study authors postulated that the differences observed between the Tricaprylin group and the other two control groups may be attributable to potential changes in nutritional status. Dams of the Tricaprylin group gained significantly less weight than those of the corn oil group during days 15-18 of gestation. However, food and water consumption were not monitored. The study authors also stated that the differences in reproductive parameters could be due to normal variation for Long-Evans rats. Additionally, the developmental toxicity of trichloroacetonitrile appeared to be vehicle-dependent; developmental effects caused by trichloroacetonitrile were seen at higher doses when administered in corn oil compared to those seen when Tricaprylin was used as the vehicle. The study authors suggested that trichloroacetonitrile and Tricaprylin “appear to interact in some way to potentiate effects of the cardiovascular system.” The adverse effects of trichloroacetonitrile in Tricaprylin were seen at doses as low as 1 mg/kg/d and included a number of different kinds of heart defects.

General safety info about Tribehenin from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 51 triglycerides; 25 of these ingredients were previously reviewed by the Panel, and 26 are reviewed herein for the first time. The majority of the ingredients named in this assessment have several functions, with most reported to function as skin conditioning agents (occlusive or emollient) and/or viscosity increasing agents in cosmetics; some are also reported to function as a fragrance or solvent. The Panel reviewed relevant new data, including frequency and concentration of use, and considered the data from previous CIR reports. The Panel concluded the 51 triglycerides reviewed in this report are safe in cosmetics in the present practices of use and concentration described in this safety assessment.

Use this, not that!

Products where you might find Tribehenin

N/A