Hydroxypropyl Cyclodextrin

The Basics On Hydroxypropyl Cyclodextrin

What is Hydroxypropyl Cyclodextrin?

A polysaccharide that is a derivative of cyclodextrin, which can be formed from starch.

What are other names for Hydroxypropyl Cyclodextrin?

HYDROXYPROPYL CYCLODEXTRIN

What is Hydroxypropyl Cyclodextrin used for?

Due to its chemical structure, it makes a complex with hydrophobic ingredients, carotenoids and other fragrance-carrying ingredients, which in turn improves the quality of color, increases the intensity of color/fragrance, water solubility and improves stability against light.

How Hydroxypropyl Cyclodextrin is classified

Miscellaneous

Recommendations for using Hydroxypropyl Cyclodextrin during pregnancy and breastfeeding

Limited data suggests no known risk

 

Hydroxypropyl Cyclodextrin During Pregnancy

What we know about using Hydroxypropyl Cyclodextrin while pregnant or breastfeeding

Limited information available.

A toxicity profile of Œ≤-cyclodextrin (a cyclic polysaccharide gum) is available from the WHO. 42 The toxicity profile of cyclodextrins can differ depending on the route of administration. For example, Œ≤-cyclodextrin administered orally induces limited toxicity. 43,44 In both rats and dogs, Œ≤-cyclodextrin is considered to be non-toxic at a daily dose less than 600 mg/kg body weight or at 3% or less in the diet. 45 However, if Œ≤-cyclodextrin is administered at higher doses in animals via a subcutaneous (s.c.) route, it will cause a decrease in body weight gain, a decrease in liver weight, and nephrotoxicity, with an increase in kidney weight, proximal tubular nephrosis and cellular vacuolation. 45,46 In another study (rats), s.c. administration of Œ≤-cyclodextrin (‚â• 450 mg/kg) induced similar changes in kidney proximal tubules.47 Acute and repeated dose toxicity studies on polysaccharide gums (according to type of exposure) are summarized in Tables 7 and Table 8, respectively. The following acute toxicity studies (according to type of exposure) on polysaccharide gums are summarized in Table 7: inhalation, oral, dermal, intravenous, intrapleural, and transbronchial. Oral and dermal repeated dose toxicity studies on polysaccharide gums are summarized in Table 8. Cytotoxicity Linear Polysaccharides and Their Salts Calcium Alginate In a cytotoxicity assay, calcium alginate fibers were introduced into human embryonic kidney cells and human fibroblasts.48 A total of nine experimental groups were prepared according to the following weights of calcium alginate fibers: 0.005, 0.01, 0.02, 0.03, 0.04, 0.05, 0.08, 0.10, and 0.15 g. Next, 1-cm lengths of fibers were cut and sterilized with UV irradiation prior to their addition to the cells. The cells were in their exponential growth phase, and were incubated for 48 h. Calcium alginate fibers were not cytotoxic. Allergenicity/Immune System Effects Non-Human Linear Polysaccharides and Their Salts Polianthes Tuberosa Polysaccharide The potential for a modulatory effect on the murine self-defense system by an acidic polysaccharide (ANK102) produced by Polianthes tuberosa cells in liquid culture was examined.49 The pretreatment (intraperitoneal [i.p.] injection) of C3H/HeN mice with ANK-102 (2 mg in 0.2 ml solution) deteriorated murine survival against lethal infection with Listeria monocytogenes, an intracellular gram positive bacterium eliminated mainly by macrophages through the T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy 1.2 expression on the surface of the thymocytes. ANK-102 was classified as an immunosuppressive polysaccharide. Potassium Carrageenan Male Sprague-Dawley rats (8 animals, 7 weeks old) were injected i.p. with potassium carrageenan (50 mg in 5 ml PBS).50 The control group received a single injection of PBS (0.5 ml). At 3 weeks post-injection, serum levels of IgM, IgG and slow Œ±1- and slow Œ±2-globulins were measured using quantitative radial immunodiffusion (IgG) or immunoelectrophoresis (IgM and slow Œ±-globulins). There was a significant elevation in levels of IgM and slow Œ±1 globulin that was maximal on day 4; levels returned to normal by day 14. Slow Œ±2-globulin was detectable within 24 h, reached a peak at day 2, and, in most animals, was no longer measurable by day 14. Levels of IgG were not affected by potassium carrageenan injection. Branched Natural/Unmodified Sterculia Urens Gum (a.k.a. Karaya Gum) The allergenicity of karaya gum was studied in adult male and female guinea pigs (number not stated).51 Karaya gum (1 g/kg) was dissolved in normal saline to make a 3% solution, which was injected i.p. The gum was also administered orally (1 g/animal daily) for 3 months, or mixed with food (single feeding of 5 g/animal). Egg albumen served as the control in each experiment. Animals that received single i.p. injections or single oral doses were killed at intervals within a range of 4 to 12 weeks after the attempted sensitization. Animals dosed orally daily for 3 months were killed either on the day after the last dose or after an interval of 6 weeks after the last dose. Isolated pieces of small intestine from treated males and females, seminal vesicles from males, and the uterus of females were suspended in an organ bath and exposed to karaya gum or egg albumen for 10 minutes. The organs of animals exposed in vivo to karaya gum where challenged first with egg albumen and, later, with karaya gum, and vice versa. Study results indicated that allergic sensitivity did not develop in guinea pigs dosed orally (single or repeated doses) or i.p. Injection of albumen resulted in marked allergic sensitization. An animal model was used to investigate the immunogenicity of karaya gum (Sterculia spp.). 52 Groups of [(C57BL/6J x DBA/2)F1] (BDF1) mice were intradermally immunized with the gum in Freund’s complete adjuvant. Serum antibody levels were measured using an enzyme-linked immunosorbent assay (ELISA), and delayed hypersensitivity responses assayed by a footpad swelling test. Karaya gum elicited systemic immune responses after immunization. Further processing reduced immunogenicity, although there was no evidence that systemic immunity to complex polysaccharide antigen responses could be completely abolished by processing or purification. Karaya gum caused considerable footpad swelling when injected intradermally. Human Branched – Modified Propylene Glycol Alginate Following a 7-day control period, 5 male volunteers consumed propylene glycol alginate at a dose of 175 mg/kg body weight for 7 days.53 This regimen was followed by dosing with 200 mg/kg body weight for an additional 16 days. No allergic responses were reported by, nor observed in, any of the volunteers. In Vitro Linear Polysaccharides and Their Salts Potassium Alginate The acute tissue reactions to potassium alginate, locally applied to a microvascular bed, were studied using the vital microscopic hamster cheek-pouch model and correlative histology.54 This experimental model permitted the study of microvascular permeability, blood flow, vessel diameters and leucocyte adhesion to vessel walls intravitally, and leucocyte migration and mast cell degranulation histologically. Deionized water alone and potassium alginate with flavor and color mixed in saline was found to cause severe microvascular alterations, while potassium alginate, without flavor and color, mixed in saline and applied to the microvasculature resulted in a minor inflammatory reaction

General safety info about Hydroxypropyl Cyclodextrin from CIR

The Cosmetic Ingredient Review Expert Panel reviewed the safety of 106 ingredients, which function as viscosity increasing agents in cosmetic products. The Panel reviewed relevant animal and human data on these ingredients. The Panel concluded that most of the polysaccharide gums are safe in the present practices of use and concentration in cosmetics, as described in this safety assessment, but that the available data are insufficient to make a determination that hydrolyzed carrageenan is safe under the intended conditions of use in cosmetics. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may be hazardous to consumers. The Panel was concerned about the presence of alkylating and other agents that are used to modify polysaccharide gums in cosmetics. Industry should use good manufacturing practices to limit impurities.

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Products where you might find Hydroxypropyl Cyclodextrin

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