Cocamidopropyl Dimethylamine

The Basics On Cocamidopropyl Dimethylamine

What is Cocamidopropyl Dimethylamine?

An antistatic agent derived from coconut oil, though it may be produced synthetically.

What are other names for Cocamidopropyl Dimethylamine?

AMIDES, COCO, N-[3-(DIMETHYLAMINO)PROPYL]-, AMIDES, COCO, N[3(DIMETHYLAMINO)PROPYL], AMIDES, SUNFLOWER SEED OIL, N-[3-DIMETHYLAMINO)PROPYL]-, AMIDOAMINE, COCAMIDOPROPYL DIMETHYLAMINE, COCAMIDOPROPYLDIMETHYLAMINE; 3-COCAMIDOPROPYLDIMETHYLAMINE; COCOAMIDOPROPYL DIMETHYLAMINE; 3-(COCOAMIDO)PROPYL-N,N-DIMETHYLAMINE; COCONUT FATTY ACID, DIMETHYLAMINOPROPYLAMIDE; COCONUT FATTY ACID, DIME, COCO N-[3-(DIMETHYLAMINO)PROPYL]- AMIDES, N-[3-(DIMETHYLAMINO)PROPYL]- AMIDES, COCO, N-[3-(DIMETHYLAMINO)PROPYL]COCO AMIDES, N-[3-DIMETHYLAMINO)PROPYL]- AMIDES, SUNFLOWER SEED OIL, and SUNFLOWER SEED OIL N-[3-DIMETHYLAMINO)PROPYL]- AMIDES

What is Cocamidopropyl Dimethylamine used for?

How Cocamidopropyl Dimethylamine is classified

Cleansing Agents

Recommendations for using Cocamidopropyl Dimethylamine during pregnancy and breastfeeding

Limited data suggests no known risk

 

Cocamidopropyl Dimethylamine During Pregnancy

What we know about using Cocamidopropyl Dimethylamine while pregnant or breastfeeding

Limited information available.

The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421. 2 Dose levels tested were 0, 20, 70 and 200 mg/kg body weight/day at a dose volume of 5 ml/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termination. Parental females were exposed 2 weeks prior to mating, during mating, during gestation, and during at least 4 days of lactation. In the 200 mg/kg males, a weight loss of up to 15% of day-1 weight was observed during the first 2 weeks of treatment, but this effect seemed to recover during the treatment period. The mean body weight and body-weight gain of the 200 mg/kg males remained statistically significantly lower throughout treatment. Females of the same dose group had statistically significant reduced body-weight gain during the first 2 weeks of treatment, as well as during gestation. Food intake was reduced during the entire premating period for males, and during the first week of the premating period for the females. Additionally, the feed consumption of the females remained slightly lower throughout pregnancy and lactation. No other treatment-related changes were observed in the parental animals. The non-statistically significant decrease in the mean number of corpora lutea was observed in the 70 and 200 mg/kg dose groups when compared with the control animal; however, a statistically significant lower number of implantation sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of living pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (i.e. mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight/day, the maternal NOAEL to be 70 mg/kg body weight/day, and the developmental NOAEL to be 200 mg/kg body weight/day. 2 In the dermal 90-day repeated dose toxicity study in rabbits described above, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmental toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rabbits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight/day at a dose volume of 2 ml/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped backs of the rabbits as a solution in 30% isopropanol and 70% reverseosmosis membrane-processed deionized water. The test sites were not occluded and were rinsed with water 2 h after each application. The rabbits were collared to prevent oral ingestion of the test material. The rabbits were observed daily during and after the dosage periods for clinical signs of toxicity, skin irritation, mortality, abortion, delivery, body weight, and feed consumption. All rabbits were killed on day 29 and complete gross necropsy was performed. Reproductive organs that were examined included the prostate, seminal vesicles, testis, epididymis in males and the ovaries, uterus, and vagina in females. The uteri were examined for pregnancy, number of implantations, live and Distributed for Comment Only — Do Not Cite or Quote dead fetuses and early and late resorptions. Corpora lutea were counted. Each fetus was weighed and subsequently examined for gross external variations and gender, prior to examination for soft tissue and skeletal variations. No mortalities were observed during the course of the study. Clinical signs attributed to administration of the test material included alopecia (5, 100, 200 mg/kg/day doses), excess lacrimation (100 and 200 mg/kg/day dosages), ungroomed coat and green-colored matted fur around mouth and rump (200 mg/kg/day dosage). Statistically significant (p‚â§0.05 to p‚â§0.01) increases in the incidences of rabbits with these signs occurred only in the mid- and high-dose groups, when compared with the controls. Dose-dependent skin reactions including atonia, desquamation and fissuring were observed in mid- and high-dose groups. One high-dose group rabbit had eschar present, attributed to the treatment. Two low-dose group rabbits aborted on day 21 of gestation and 1 rabbit in the high-dose group delivered prematurely; however, these events were not test material-related. Body weight gains were significantly decreased in the mid-dose (p‚â§0.05) and high-dose (p‚â§0.01) group animals. High dose group animals had a significant decrease (p‚â§0.01) in average body weight during treatment, and continued to have lower average body weights than control rabbits during the post dosage period. Body weights and bodyweight gain of lowdose group rabbits were comparable to control values. When compared to the control values, maternal feed consumption was affected in the mid- and high-dose groups, with the average daily feed consumption of the highdose group rabbits significantly decreased (p‚â§0.05 to p‚â§0.0.1) from Day 15 through Day 21 of gestation. Slightly impaired implantation was observed, along with slightly decreased litter sizes, in the 200 mg/kg dose when compared to the control group, but this effect was not statistically significant (p>0.05). All of the values were within expected historical control values. The test material did not adversely affect pregnancy incidence or average numbers of corpora lutea or resorptions. Viable fetuses were present in 20, 14, 17, and 14 litters from control, low, middle, and high dosage groups, respectively. One rabbit each from low and high dose group had all implantations resorbed. No treatment-related fetal variations at gross external, soft tissue or skeletal examination were observed. The researchers concluded that dermal application of stearamidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxicity. The maternal NOEL was determined to be 5 mg/kg body weight/day, the maternal NOAEL was determined to be100 mg/kg body weight/day based on variations in body weight and food-consumption data, and the developmental NOAEL was determined to be 200 mg/kg body weight/day in this study

General safety info about Cocamidopropyl Dimethylamine from CIR

The Cosmetic Ingredient Review Expert Panel reviewed the safety of fatty acid amidopropyl dimethylamines, which function primarily as antistatic agents in cosmetic products. The relevant animal and human data reviewed for these ingredients indicate that they are potential dermal sensitizers. The Panel concluded that fatty acid amidopropyl dimethylamines were safe as cosmetic ingredients when they are formulated to be non-sensitizing.

Use this, not that!

Products where you might find Cocamidopropyl Dimethylamine

N/A