Acacia Senegal Gum

The Basics On Acacia Senegal Gum

What is Acacia Senegal Gum?

Herb that can have skin soothing properties, but is used primarily as a thickening agent.

What are other names for Acacia Senegal Gum?

GUM ARABIC, ACACIA GUM, ACACIA GUM (ACACIA SENEGAL (L.) WILLD.), ACACIA SENEGAL GUM, and GUM ARABIC

What is Acacia Senegal Gum used for?

Wild Acacia (aka, Acacia Senegal Gum) when used in a facial cosmetic, it’s as an adhesive, though it’s also used for its emollient and occlusive properties‚Äìit helps “lock in” moisture. According to most cosmetic companies, wild acacia is clinically proven to decrease wrinkle depth and appearance.

How Acacia Senegal Gum is classified

Texture Enhancer, Plant Extracts, Skin-Soothing

Recommendations for using Acacia Senegal Gum during pregnancy and breastfeeding

Limited data suggests no known risk

 

Acacia Senegal Gum During Pregnancy

What we know about using Acacia Senegal Gum while pregnant or breastfeeding

Limited information available.

Studies on the reproductive and developmental toxicity of gum arabic are summarized in Table 11 and discussed below. The antifertility activity of Gum Acacia (1 ml in water) was evaluated using 10 female rats (strain and weights not stated). The test substance was administered by stomach tube daily for a period of 5 days after mating. After performing laparotomy on anesthetized dams, the number of fetuses was counted on the 10 day of pregnancy. The average number of implants per rat was 7.8. The percentage of rats with no implant was 0 (Sabir and Razdan 1970). In a study by the Food and Drug Research Laboratories (1972), the teratogenicity of gum arabic was evaluated using six TABLE 11 Reproductive and developmental toxicity studies Test substance Animals/cells tested Test procedure Test results References Acacia 10% aqueous Acacia solution 9 Little Dutch female rabbits (average weight between 2.1 kg) After mating, 10% aqueous Acacia solution administered orally on day 0 and the following 6 days Normal microscopic variations in blastocysts reported: minor trophoblastic vacuolation, trophoblastic degeneration granules, and trophoblastic knob formations Schardein et al. 1965 Gum Acacia 10 female rats Gum Acacia (1 ml in water) administered orally during 5-day period after mating No antifertility activity. Average number of implants per rat = 7.8 Sabir and Razdan 1970 Gum Acacia Two groups of 5 male albino Wistar rats (4 months old; weights between 180 to 200 g) First group dosed orally (dose = 1 ml) daily for 24 days. Second group dosed orally (dose = 1 ml) for 48 days No suppression of spermatogenesis Akbarsha and Manivannan 1973 4% Gum Acacia 6 Haffkine albino rabbits (weights between 175 to 225 g) Males dosed orally daily for 28 days and mated with untreated females for total of 12 weeks No statistically significant difference in number of pregnant females. No antifertility effect in males Yegnanarayan and Joglekar 1978 Adult female rabbits (weights between 1 to 2 g) Dosed orally with 4% Gum Acacia for two days No inhibitory effect on ovulation Female albino rats (weights between 150 to 200 g) 4% Gum Acacia administered orally to 10 females over period of two estrus cycles, followed by mating with males during proestrus phase of third estrus cycle (short-term experiment). 4% Gum Acacia administered orally to 6 females over period of 6 estrus cycles, followed by mating during proestrus stage of 7th estrus cycle No significant differences in mating (number of females inseminated) between experimental and control groups. No significant changes in duration of estrus cycles after dosing (Continued on next page) 103 TABLE 11 Reproductive and developmental toxicity studies (Continued) Test substance Animals/cells tested Test procedure Test results References 10 female rats (weights between 150 to 200 g) Females dosed orally with 4% gum arabic on days 1 to 7 of pregnancy No statistically significant difference in average litter sizes between experimental and control groups, indicating that fetal resorption did not occur 10 female rats (weights between 150 to 200 g) Females dosed orally with 4% gum arabic on days 10 to 16 of pregnancy No statistically significant differences in number of pups delivered between experimental and control groups 5% Gum Acacia 9 Syrian golden hamsters (8 weeks old; weights between 80 to 100 g) Dosed orally with 5% Gum Acacia (dose volume = 0.1 ml/10 g body weight) daily for 54 days All of the hamsters produced morphologically normal sperm Waller et al. 1983 1% Gum Acacia 10 female Charles Foster rats (90 days old; weights between 200 ± 20 g) Administered daily at dose of 50 mg/kg/day during the period of organogenesis No gross or visceral defects Sethi et al. 1989 Gum Arabic 1% aqueous suspension or mucilage prepared from gum arabic NMRI mice 1% aqueous suspension or mucilage prepared from gum arabic injected intraperitoneally (single injection or series of 5 injections), subcutaneously (5 injections), and administered orally (5 times) between the 11th and 15th day of gestation No lethal effects on fetuses Frohberg et al. 1969 Gum Arabic Adult female albino CD-1 outbred mice (4 groups). Most groups contained 22 to 23 mice The four groups of mated mice received oral doses of 16, 75, 350, and 1600 mg/kg on days 6 through 15 of gestation The number of abnormalities observed in soft or skeletal tissues of fetuses did not differ from the number occurring spontaneously in sham-treated controls Food and Drug Research Laboratories 1972 Groups of female rats, rabbits, and hamsters Oral doses of 16, 75, 350, and 1600 mg/kg on gestation days 6 through 10 (hamsters) and 6 through 15 (rats). Oral doses of 8, 37, 173, and 800 mg/kg in corn oil on days 6 through 18 of gestation (rabbits) The number of abnormalities observed in soft or skeletal tissues of fetuses did not differ from sham-treated controls 104 Gum Arabic (Acacia Senegal Gum) Groups of 4-week-old Osborne-Mendel (FDA strain) rats Groups fed dietary concentrations up to 15% beginning at week 13 prior to mating Gum Arabic not classified as a reproductive or developmental toxicant in rats Collins et al. 1987 5% aqueous gum arabic solution 36 female Sprague-Dawley Crl:CDBR rats (∼9 months; weights between 207 to 314 g) Solution administered orally once daily (5 ml/kg/day) on days 6 through 17 of gestation External, visceral, and skeletal malformations observed were unrelated to dosing with Acacia Morseth and Ihara 1989a 5% aqueous gum arabic solution 30 male Sprague-Dawley Crl:CDBR male rats (6 weeks old; weights between 181.9 to 226.3 g) 30 female rats of same strain (10 weeks old; weights between 210.9 to 309.9 g) Solution administered orally to females once daily (5 ml/kg/day) for 14 days prior to mating, throughout the mating period, and through day 19 of gestation or day 21 of lactation. Solution also administered to males prior to and during mating and until animals killed No treatment-related abnormal estrous cycles. No external, skeletal, or soft tissue malformations Morseth and Ihara 1989b Gum Arabic 12 Sprague-Dawley rats (adult males) Control rats fed 30% gum arabic in the diet for 82 days No effect on spermatogenesis (all males were fertile) Huynh et al. 2000 105 106 COSMETIC INGREDIENT REVIEW groups of mated adult female albino CD-1 outbred mice. Three of the test groups consisted of 22 to 23 mice per group and received doses of 16, 75, and 350 mg/kg, respectively, on days 6 through 15 of gestation. Doses were administered by oral intubation. The fourth test group of 31 mice was dosed with gum arabic (1600 mg/kg) according to the same procedure. Sham-treated mice (28) served as negative controls, and positive-control mice were dosed with aspirin (150 mg/kg). Mean body weights for the test groups ranged from 30 to 39.7 g and were 31.2 g and 31.8 g for negative and positive controls, respectively. On day 17, all dams were placed under anesthesia and cesarean section was performed. The numbers of implantation sites, resorption sites, and live and dead fetuses were recorded. The urogenital tract of each dam was examined in detail for anatomical normality. Gross examinations for the presence of external congenital abnormalities were performed on all fetuses. Detailed visceral examinations employing 10× magnification were performed on one-third of the fetuses from each litter. The remaining two-thirds were examined for skeletal defects. The administration of gum arabic to pregnant mice at doses up to 1600 mg/kg had no clearly discernible effect on nidation or maternal or fetal survival. The number of abnormalities observed in either soft or skeletal tissues of fetuses from test groups did not differ from the number occurring spontaneously in sham-treated controls. As part of this study, groups of rats, rabbits, and hamsters were dosed with gum arabic according to the following modifications of the above test procedure: doses (indicated above) were administered to hamsters (gestation days 6 through 10), rats (gestation days 6 through 15), and rabbits (gestation days 6 through 18). Cesarean sections were performed earlier on hamsters (day 14) and later on rats (day 20). Positive-control rats and hamsters received a higher dose of aspirin (250 mg/kg). Rabbits were dosed with gum arabic in corn oil (8, 37, 173, and 800 mg/kg, respectively); cesarean sections were performed on day 29. Rabbits were injected with human chorionic gonadotropin (day 0) and artificially inseminated. Mean weights for the dams tested were as follows: 200 to 216 g (24 rats per group), 104.6 to 118.4 g (21 to 24 hamsters per group), and 2.01 to 2.43 kg (15 rabbits per group). The administration of gum arabic, in corn oil, to pregnant rabbits at doses up to 37 mg/kg (highest dose tested = 800 mg/kg) had no clear effect on nidation or maternal or fetal survival. The number and types of abnormalities observed in fetal soft or skeletal tissues from this group did not differ from the number occurring spontaneously in the sham-treated controls. Of the four test groups of rabbits (15 dams per group), the number of survivors per dose group was reported as follows: 13 rabbits (8.0 mg/kg dose group), 15 rabbits (37.0 mg/kg), 12 rabbits (173.0 mg/kg), and 9 rabbits (800.0 mg/kg). In 173 and 800 mg/kg dose groups, maternal death was preceded by severe bloody diarrhea, urinary incontinence, and anorexia. At necropsy, hemorrhage in the mucosa of the small intestines was the only gross pathological finding (Food and Drug Research Laboratories 1972). Akbarsha and Manivannan (1993) studied the reproductive toxicity of Gum Acacia using two groups of five male albino rats of the Wistar strain (4 months old; weights between 180 and 200 g). The test substance was administered orally (dose = 1 ml) to the first group daily for 24 days. The second group was dosed (dose = 1 ml) daily for 48 days. Rats in both groups were necropsied 24 h after the last dose. The testis, epididymis (divided into caput and cauda), seminal vesicle, ventral prostate, and coagulating gland were excised, homogenized, and centrifuged. The supernatant was used for determination of total protein and acid phosphatase (ACPase) and alkaline phosphatase (ALPase) activities. Supernatant obtained from the testes was also used for the determination of glycogen and cholesterol, and lactate dehydrogenase (LDH) activity. The authors stated that increased glycogen and LDH in the testis are both consequences of spermatogenic arrest, and that decreased ACPase and increased ALPase activities in the testis also reflect the suppression of spermatogenesis. They concluded that Gum Acacia did not suppress spermatogenesis in this study (Akbarsha and Manivannan 1993). Huynh et al. (2000) used gum arabic as the vehicle control in a study evaluating the effect of triptolide (deterpene triepoxide) on spermatogenesis in adult male Sprague-Dawley rats (12 animals, 90 days old). Control males were fed 30% gum arabic in the diet daily for 82 days. Males in the test group were each fed triptolide at a daily dose of 100 μg/kg body weight. Male and female rats (two females per male) were housed together during the feeding period, after which pregnancy rates were determined. The presence of sperm in morning vaginal smears was used to determine whether or not mating was successful. Any male that impregnated at least one of the females was considered fertile. All 12 control males were fertile, whereas all males fed triptolide in the diet were sterile. Collins et al. (1987) evaluated the teratogenicity of gum arabic (Acacia Senegal Gum) using groups of 4-week-old OsborneMendel (FDA strain) rats. Beginning at 13 weeks prior to mating, the rats were fed gum arabic at concentrations of 1%, 2%, 4%, 7.5%, or 15%, respectively. Another group of rats was fed a control diet. Control and test diets were also fed throughout mating and gestation. After mating was confirmed, females were placed in groups of 41 to 47. The dams were killed on day 20 of gestation. One female rat (1% dietary group) died during the study. External observations of the dams were unremarkable. One female (7.5% dietary group) did have a cystic ovary and one had lung nodules (15% dietary group). Sporadic nonsignificant increases in body weight were observed in all experimental groups. The percentage of pregnant females was approximately the same in all experimental groups and controls. Mean numbers of corpora lutea and implants per female were also similar to control values, and the average number of viable fetuses was similar in all groups. No effect was seen in any group with ACACIA 107 respect to the mean number of viable males and females. Three litters were totally resorbed, one litter from the control, 1%, and 4% dietary groups. Gum arabic in the diet had no effect on the percentage of females with at least one resorption or with at least two resorptions. The numbers of early and late deaths, singly or combined (as average percentage of resorptions), were similar to control values. The feeding of gum arabic had no effect on mean fetal body weights and crown-rump lengths. The ingestion of gum arabic also had no effect on the distribution of fetuses by sex. A significant decrease in mean female body weight in the 1% dietary group was noted; however, this observation was deemed a random occurrence. The significant increase in the length of females in the 4% and 7.5% dietary groups was not considered biologically significant. The investigators stated that because of the large group of animals in this study, small variations in crown-rump length can result in significant effects. Similar numbers of runts were noted among male and female fetuses from all dietary groups, with the exception of no runts among male fetuses in the 1% and 15% dietary groups. Regarding external variations in live fetuses, spina bifida and exencephaly were observed in two fetuses from the control group. No other terata were observed, and the external variations were distributed randomly. Similar numbers of fetuses with hemorrhages were observed in all dietary groups. The mean numbers of sternebral variations per litter varied from 4.18 (4% gum arabic dietary group) to 5.09 (15% dietary group) in experimental groups, and the mean number of sternebral variations per litter in the control group was 5.21. The variations included reduced ossification and bipartite, missing, and malaligned sternebrae. No dose-related increases were found with respect to any of the observed sternebral deficiencies, and no significant differences were found between experimental and control groups. The significant decrease in the average number of fetuses with one or more sternebral variations per litter that was observed in the 4% and 7.5% dietary groups was considered a random occurrence. Thus, the ingestion of gum arabic did not affect the incidence of litters with fetuses with sternebral variations. Skeletal ossification deficiencies were observed in bones other than sternebrae; however, no dose-related differences were observed between experimental and control groups with respect to any variation. Furthermore, no dose-related effect was found on the incidence of variations, fetuses with variations, or litters affected in any of the dietary groups. Also, no dose-related effect was observed on the incidence of any type of soft-tissue variation. Most of the soft tissue variations involved the kidneys. Additionally, the incidence of soft tissue variations in fetuses from experimental and control groups was similar. The mean numbers of soft tissue variations per litter ranged from 0.30 (15% dietary group) to 0.82 (7.5% dietary group), and the mean was 0.76 per litter in the control group (Collins et al. 1987). Schardein et al. (1965) administered a 10% aqueous Acacia solution by gavage to two groups of nine Little Dutch strain mated female rabbits (average weight = 2.1 kg) at doses of 1.26 and 1.5 ml/kg, respectively. Doses were administered on day 0 and the following 6 days (7 doses per female). Nine untreated rabbits served as negative controls. Blastocysts were removed from the uterine horns at 6.5 days of age, prepared as flat mounts, and then evaluated. The number of fertile rabbits with blastocysts recovered (eight of nine rabbits) in the 1.26 and 1.5 ml/kg dose groups was the same as that noted for the untreated control group. The mean numbers of blastocysts per rabbit were as follows: untreated controls (5.3 ± 1.2), 1.26 ml/kg dose group (7.0 ± 1.7), and 1.5 ml/kg dose group (5.4 ± 2.2). Normal microscopic variations in blastocysts were reported for test and control groups. These variations included minor trophoblastic vacuolation, trophoblastic degeneration granules, and trophoblastic knob formations (Schardein et al. 1965). Morseth and Ihara (1989a) studied the teratogenicity of a 5% solution of gum arabic (powder) in distilled water using 36 female Crl: CDBR rats (∼9 months old) for which mating had been confirmed. Body weights on gestation day 0 ranged from 207 to 314 g. The solution was administered by gavage once daily (5 ml/kg/day) on gestation days 6 through 17. The dams were necropsied on day 20 of gestation. Fetuses were subjected to external (303 fetuses), visceral (102 fetuses), and skeletal (201 fetuses) examinations. External variations were not observed in any of the fetuses evaluated; however, external malformations, brachygnathia and rudimentary/short tail, were observed in one fetus. Visceral variations included only two fetuses with increased renal pelvic cavitation. At skeletal evaluation, one fetus had brachygnathia, tail short/rudimentary, abnormal fusion of sternebrae, and vertebral anomaly with/without associated rib anomaly. The external, visceral, and skeletal malformations observed were unrelated to dosing with Acacia (Morseth and Ihara 1989a). Morseth and Ihara (1989b) evaluated the effect of a 5% solution of gum arabic (powder) in distilled water on fertility and general reproductive performance using 30 male (6 weeks old; weights = 181.9 to 226.3 g) and 30 female (10 weeks old; weights = 210.9 to 309.9 g) Sprague-Dawley Crl: CDBR rats. The solution was administered (oral intubation) to male and female rats once daily (5 ml/kg/day) for 63 days prior to mating, throughout the mating period, and until the animals were killed. Male rats were killed after the females had littered. The oral dosing schedule for female rats was daily for 14 days prior to mating, throughout the mating period, and through gestation day 19 or day 21 of lactation. Fifteen female rats were killed on day 20 of gestation, and the remaining females were allowed to raise their neonates to day 22 postpartum. No abnormal estrous cycles that were considered treatmentrelated were observed in any of the females. Twenty-nine of the 30 females became pregnant; the male fertility index was 97%. Mean viability and mean weaning indices were 96% and 98%, 108 COSMETIC INGREDIENT REVIEW respectively. No external, skeletal, or soft tissue malformations were observed (Morseth and Ihara 1989b). The reproductive toxicity of 5% Gum Acacia was evaluated using nine male Syrian golden hamsters (8 weeks old; weights = 80 to 100 g). The males were mated with female Syrian golden hamsters in order to confirm fertility. Subsequently, the males were dosed (oral gavage) with 5% Gum Acacia (dose volume = 0.1 ml/10 g body weight) daily for 54 days. The animals were killed 3 days after the last dose. As determined by analysis of testis sections, spermatogenesis was reported for all hamsters. All of the hamsters produced morphologically normal sperm, which were also observed in the epididymis (Waller et al. 1983). Yegnanarayan and Joglekar (1978) studied the antifertility effects of 4% Gum Acacia in a series of five experiments using male and female rats and female rabbits of the Haffkine strain. In the first study, six male albino rats (weights = 175 to 225 g) were tested. The rats were dosed orally daily for 28 days using a rubber catheter. Beginning on the first day of feeding, males were mated (one male to two females) with females for 12 weeks. Females were replaced each week of feeding. Additional groups of females were mated with control males dosed with saline according to the same procedure. Vaginal smears were examined daily for the presence of spermatozoa. Pregnant females were surgically observed on the tenth day of pregnancy. The number of inseminated females (73) was the same in experimental and control groups. The total number of pregnant females in experimental and control groups was 24 and 37, respectively, but this difference was not statistically significant. In the second experiment, the effect of 4% Gum Acacia on the estrus cycle and mating was evaluated using fertile female albino rats (weights = 150 to 200 g). The experiment was divided into two phases. In the first phase (short-term treatment), 4% Gum Acacia was administered orally to 10 female rats over a period of two estrus cycles, beginning on the day of proestrus. The females were mated singly with males during the proestrus phase of the third estrus cycle. In the second phase (long-term treatment), 4% Gum Acacia was administered orally to six female rats over a period of six estrus cycles, beginning in the proestrus phase. Mating was allowed in the proestrus stage of the seventh estrus cycle. In both the first and second experimental phases, control females dosed with saline were mated with males according to the same procedures, respectively. Results for the first and second phases of this experiment indicated no significant differences in mating (number of females inseminated) between experimental and control groups. Additionally, for both phases, no significant changes were observed in the duration of estrus cycles after dosing. The third experiment, for determining anti-implantation effects, involved 10 fertile rats (weight range from 150 to 200 g) that were mated in proestrus singly with fertile males. Females were dosed orally with 4% gum arabic on days 1 to 7 of pregnancy. The animals were allowed to deliver normally and litter sizes were recorded. Ten control females dosed with saline were mated according to the same procedure. No statistically significant differences were observed in average litter sizes between experimental and control groups, indicating that fetal resorption did not occur in litters of rats dosed with 4% gum arabic. The fourth experiment was performed to determine any postimplantation effect of 4% gum arabic using ten fertile rats (weights = 150 to 200 g). Female rats were dosed orally with 4% gum arabic on days 10 to 16 and the number of pups delivered was determined. The rats were observed for vaginal bleeding, indicative of abortifacient activity during pregnancy. Control females were dosed with saline according to the same procedure. One of 10 experimental rats did not have a litter. All control females had litters. No statistically significant differences were observed in the number of pups delivered between experimental and control groups. In the fifth experiment, the antiovulatory potential of 4% Gum Acacia was evaluated using adult female rabbits (number not stated; weights = 1 to 2 kg). The rabbits were dosed orally with 4% gum arabic for 2 days. Copper acetate (4 mg/kg) was then injected into the marginal ear vein in order to induce ovulation. At 48 h post injection, laparotomy was performed; fresh bleeding points on the ovaries were indicative of ovulation. Control rabbits were pretreated with saline according to the same procedure prior to the injection of copper acetate. After the injection of copper acetate, bleeding points on the ovaries were observed in all control and experimental rabbits. Therefore, the authors concluded that 4% Gum Acacia did not have an inhibitory effect on ovulation (Yegnanarayan and Joglekar 1978). A 1% aqueous suspension or mucilage prepared from gum arabic had no lethal effects on fetuses of NMRI mice injected intraperitoneally (single injection or series of five injections), subcutaneously (five injections), or administered orally (five times) between the 11th and 15th day of gestation (Frohberg et al. 1969). The embryotoxicity of 1% Gum Acacia was evaluated using ten Charles Foster rats (90 days old; weights = 200 ± 20 g). The test substance was administered daily at a dose of 50 mg/kg/day during the period of organogenesis. The fetuses were delivered by cesarean section on day 20 of gestation, fixed in Bouin’s solution, and examined for visceral and skeletal defects. None of the fetuses had gross or visceral defects (Sethi et al. 1989).

General safety info about Acacia Senegal Gum from CIR

These ingredients are derived from various species of the acacia plant. Only material derived from Acacia senegal are in current use according to industry data. The concentration at which these ingredients are reported to be used ranges from 9% in mascara to 0.0001% in tonics, dressings, and other hair-grooming aids. Gum arabic is a technical name for Acacia Senegal Gum. Gum arabic is comprised of various sugars and glucuronic acid residues in a long chain of galactosyl units with branched oligosaccharides. Gum arabic is generally recognized as safe as a direct food additive. Little information is available to characterize the extracts of other Acacia plant parts or material from other species. Acacia Concinna Fruit Extract was generally described as containing saponins, alkaloids, and malic acid with parabens and potassium sorbate added as preservatives. Cosmetic ingredient functions have been reported for Acacia Decurrens Extract (astringent; skinconditioning agent—occlusive) and Acacia Farnesiana Extract (astringent), but not for the other Acacias included in this review. Toxicity data on gum arabic indicates little or no acute, short-term, or subchronic toxicity. Gum arabic is negative in several genotoxicity assays, is not a reproductive or developmental toxin, and is not carcinogenic when given intraperitoneally or orally. Clinical testing indicated some evidence of skin sensitization with gum arabic. The extensive safety test data on gum arabic supports the safety of Acacia Senegal Gum and Acacia Senegal Gum Extract, and it was concluded that these two ingredients are safe as used in cosmetic formulations. It was not possible, however, to relate the data on gum arabic to the crude Acacias and their extracts from species other than Acacia senegal. Therefore, the available data were considered insufficient to support the safety of Acacia Catechu Gum, Acacia Concinna Fruit Extract, Acacia Dealbata Leaf Extract, Acacia Dealbata Leaf Wax, Acacia Decurrens Extract, Acacia Farnesiana Extract, Acacia Farnesiana Flower Wax, Acacia Farnesiana Gum, and Acacia Senegal Extract in cosmetic products. The additional data needed to complete the safety assessment for these ingredients include (1) concentration of use; (2) identify the specific chemical constituents, and clarify the relationship between crude Acacias and their extracts and the Acacias and their extracts that are used as cosmetic ingredients; (3) data on contaminants, particularly relating to the presence of pesticide residues, and a determination of whether Acacia melanoxylon is used in cosmetics and whether acamelin (a quinone) and melacacidin (a flavin) are present in the Acacias that are being used; (4) skin sensitization study (i.e., dose response to be determined); (5) contact urticaria study at use concentration; and (6) ultraviolet (UV) absorption spectrum; if there is significant absorbance in the UVA or UVB range, then a photosensitization study may be needed. It was also noted that other data may be needed after clarification of the chemical constituents of the Acacia-derived ingredients.

Use this, not that!

Products where you might find Acacia Senegal Gum

Supersmile Professional Whitening Gum (12 piece); PerioSciences AO ProVantage (1 fl. oz.); PerioSciences Antioxidant Oral Care System Sensitive (3 piece); Anastasia Beverly Hills Lash Brag Volumizing Mascara; Drybar Southern Belle Volume-Boosting Root Lifter; Anastasia Beverly Hills Lash Brag Volumizing Mascara Mini