Glycerol Triacetate

The Basics On Glycerol Triacetate

What is Glycerol Triacetate?

Used as an emollient and thickening agent in cosmetics.

What are other names for Glycerol Triacetate?

N/A

What is Glycerol Triacetate used for?

Triacetin helps cleanse the skin or prevent odor by destroying or inhibiting the growth of microorganisms. It is also a plasticizer and commonly used carrier for flavors and fragrances. Scientific Facts: Triacetin, or Glyceryl Triacetate, is a naturally occurring oil found in cod-liver oil, butter and other fats.

How Glycerol Triacetate is classified

Thickeners/Emulsifiers, Emollients

Recommendations for using Glycerol Triacetate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Glycerol Triacetate During Pregnancy

What we know about using Glycerol Triacetate while pregnant or breastfeeding

Limited information available.

In a 2-generation reproductive study in rats, (n=10/sex), the administration of glycerin (0, 20%; ~ 2000 mg/kg/d in drinking water) for 8 weeks before mating until weaning of pups produced no adverse effects on the reproductive efficiency of the parents (F0 generation), or the growth, fertility, or reproductive performance of the untreated F1 generation.2 No histological changes occurred in the tissues of either the F1 or F2 generations. The onset of estrus cycles, weight gain, and microscopic observations of the endocrine organs were comparable to those of the controls in both the F1 and the F2 generation. In the F0 generation, all 10 females became pregnant with similar litter size as controls (9.0 vs. 8.1). In the F1 generation, 9 of 10 females became pregnant. When glycerin (13.1, 60.8, 282, and 1310 mg/kg/d) was administered by gavage to Wistar rats (n=25-28) on days 6 through 15 of gestation, there were no adverse effects observed in the dams.37 The NOAEL for maternal toxicity and teratogenicity was 1310 mg/kg/d. The number of pregnancies was: 23 of 25, 24 of 25, 22 of 28, 22 of 25 for 13.1, 60.8, 282 and 1310 mg/kg/d, respectively, and 21 of 25 for controls. The number of implantations, resorptions, litter sizes, weights, and sex ratio were similar among groups, as were the incidences of external, visceral, and skeletal abnormalities. When glycerin (12.8, 59.4, 276 and 1280 mg/kg/d) was administered by gavage to CD-1 mice (n=25) on days 6 through 15 of gestation, there were no adverse effects observed in the dams.37 The NOAEL for maternal toxicity and teratogenicity was 1280 mg/kg/d. The number of pregnancies was: 14 of 15, 12 of 15, 10 of 18, 13 of 20 and 13 of 15 for controls, 12.8, 59.4, 276 and 1280 mg/kg, respectively. The number of implantations, resorptions, litter sizes, weights, and sex ratio were similar among groups as were external, visceral, and skeletal abnormalities. When glycerin (11.8, 54.8, 254.5 and 1180 mg/kg/d) was administered by gavage to Dutch-belted rabbits (n=25) on days 6 through 18 of gestation, there were no adverse effects found in the dams.37 The NOAEL for maternal toxicity and teratogenicity was 1180 mg/kg/d. The number of pregnancies was: 22 of 25, 23 of 25, 20 of 25, 22 of 25 and 21 of 25 for controls, 11.8, 54.8, 254.5 and 1180 mg/kg/d, respectively. The number of implantations, resorptions, litter sizes, weights, and sex ratio were similar among groups, as were external, visceral, and skeletal abnormalities

General safety info about Glycerol Triacetate from CIR

This is a safety assessment of glycerin as used in cosmetics. Glycerin functions as a denaturant; fragrance ingredient; hair conditioning agent; humectant; oral care agent; oral health care drug; skin protectant; skin-conditioning agent – humectant; and viscosity decreasing agent. The Panel reviewed relevant animal and human data related to the ingredient. The Panel concluded that glycerin was safe as a cosmetic ingredient in the practices of use and concentration described in this safety assessment.

Use this, not that!

Products where you might find Glycerol Triacetate

Fresh Lotus Youth Preserve Radiance Lotion