Aflibercept

The Basics

What is Aflibercept?

Used to treat wet macular degeneration and metastatic colorectal cancer.

Brand names for Aflibercept

Eylea

How Aflibercept is classified

Protein Kinase Inhibitors, Tyrosine Kinase Inhibitors

Aflibercept During Pregnancy

Aflibercept pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Aflibercept while pregnant

N/A

Taking Aflibercept While Breastfeeding

What are recommendations for lactation if you're taking Aflibercept?

This record refers to the use of intravitreal aflibercept for macular degeneration. No information is available on the use of aflibercept during breastfeeding. The manufacturer estimates that after intravitreal administration of 2 mg, the mean maximum plasma concentration of free aflibercept is more than 100-fold lower than the concentration of aflibercept required to half-maximally bind systemic vascular endothelial growth factor. Additionally, aflibercept is a large protein molecule with a molecular weight of 115,000, Therefore, the amount in breastmilk is likely to be clinically unimportant after intravitreal injection. However, the manufacturer recommends avoiding the drug during breastfeeding.

Maternal / infant drug levels

This record refers to the use of intravitreal aflibercept for macular degeneration. No information is available on the use of aflibercept during breastfeeding. The manufacturer estimates that after intravitreal administration of 2 mg, the mean maximum plasma concentration of free aflibercept is more than 100-fold lower than the concentration of aflibercept required to half-maximally bind systemic vascular endothelial growth factor. Additionally, aflibercept is a large protein molecule with a molecular weight of 115,000, Therefore, the amount in breastmilk is likely to be clinically unimportant after intravitreal injection. However, the manufacturer recommends avoiding the drug during breastfeeding.

Possible effects of Aflibercept on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Aflibercept

None listed