The Basics
What is Alosetron?
Used to treat diarrhea, pain, cramps, and the feeling of an urgent need to have bowel movements caused by IBS.
Brand names for Alosetron
Lotronex
How Alosetron is classified
Gastrointestinal Agents, Serotonin Antagonists
Alosetron During Pregnancy
Alosetron pregnancy category
Category BNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Alosetron while pregnant
Reproduction studies have beenperformed in rats at doses up to 40 mg/kg/day (about 160 times the recommended human dose basedon body surface area) and rabbits at oral doses up to 30 mg/kg/day (about 240 times therecommended daily human dose based on body surface area). These studies have revealed noevidence of impaired fertility or harm to the fetus due to alosetron. There are, however, no adequateand well-controlled studies in pregnant women. Because animal reproduction studies are not alwayspredictive of human response
Taking Alosetron While Breastfeeding
What are recommendations for lactation if you're taking Alosetron?
No information is available on the use of alosetron during breastfeeding. Because of relatively high protein binding and only moderate bioavailability, exposure of the breastfed infant is likely to be low. Until more data are available, alosetron should only be used with careful infant monitoring during breastfeeding.
Maternal / infant drug levels
No information is available on the use of alosetron during breastfeeding. Because of relatively high protein binding and only moderate bioavailability, exposure of the breastfed infant is likely to be low. Until more data are available, alosetron should only be used with careful infant monitoring during breastfeeding.
Possible effects of Alosetron on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Alosetron
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/None listed
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
