The Basics
What is Amanita Mushroom Poisoning?
Ingestion of Amanita phalloides is responsible for a majority of mushroom-related deaths worldwide. Amatoxins, the principal toxic alkaloids found in these fungi, cause cell injury by halting protein synthesis.
Brand names for Amanita Mushroom Poisoning
N/A
How Amanita Mushroom Poisoning is classified
Foodborne Diseases, Poisoning
Amanita Mushroom Poisoning During Pregnancy
Amanita Mushroom Poisoning pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Amanita Mushroom Poisoning while pregnant
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Taking Amanita Mushroom Poisoning While Breastfeeding
What are recommendations for lactation if you're taking Amanita Mushroom Poisoning?
Amatoxins are water soluble, heat stable polypeptides found in Amanita (most often Amanita phalloides ), Galerina and some Lepiota species. The main toxin from the species A. phalloides is alpha-amanitin, a cyclic octapeptide. It is a potent inhibitor of RNA polymerases that blocks the production of mRNA and protein synthesis in liver and kidney cells.[1] Although some articles and textbooks state that amatoxins pass into breastmilk, documentation is very poor except for one recent case, which might refute this assertion. Nevertheless, mothers suspected of having mushroom poisoning should not breastfeed until they have recovered.
Maternal / infant drug levels
Amatoxins are water soluble, heat stable polypeptides found in Amanita (most often Amanita phalloides ), Galerina and some Lepiota species. The main toxin from the species A. phalloides is alpha-amanitin, a cyclic octapeptide. It is a potent inhibitor of RNA polymerases that blocks the production of mRNA and protein synthesis in liver and kidney cells.[1] Although some articles and textbooks state that amatoxins pass into breastmilk, documentation is very poor except for one recent case, which might refute this assertion. Nevertheless, mothers suspected of having mushroom poisoning should not breastfeed until they have recovered.
Possible effects of Amanita Mushroom Poisoning on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Amanita Mushroom Poisoning
None listed
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Hydzik P, Bielanski W, Ponka M et al. Usefulness of 13C-methacetin breath test in liver function testing in Amanita phalloides poisoning; breast feeding woman case. Clin Toxicol (Phila). 2008;46:1077-82. PMID: 18821093
2. Shively RM, Nogar JN, Rella JG et al. Got milk? A case series of an amatoxin-exposed family, including a breastfeeding mother and infant. Clin Toxicol (Phila). 2019;1-2. PMID: 31070058
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
