The Basics
What is Bivalirudin?
Widely used to treat high blood pressure and prevent future strokes, heart attacks and kidney problems.
Brand names for Bivalirudin
Angiomax
How Bivalirudin is classified
Anticoagulants, Antithrombins
Bivalirudin During Pregnancy
Bivalirudin pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Bivalirudin while pregnant
There are no data available on use of Angiomax in pregnant women to inform a drug-associated risk of adverse developmental outcomes. Reproduction studies in rats and rabbits administered subcutaneously doses up to 1.6 times and 3.2 times the maximum recommended human dose (MRHD) of 15 mg/kg/day based on body surface area (BSA) during organogenesis, respectively, revealed no evidence of fetal harm. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2–4% and 15–20%, respectively.
Taking Bivalirudin While Breastfeeding
What are recommendations for lactation if you're taking Bivalirudin?
Because no information is available on the use of bivalirudin during breastfeeding, an alternate drug is preferred.[1]
Maternal / infant drug levels
Because no information is available on the use of bivalirudin during breastfeeding, an alternate drug is preferred.[1]
Possible effects of Bivalirudin on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Bivalirudin
Acenocoumarol, Dalteparin, Enoxaparin, Heparin, Warfarin.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Bates SM, Greer IA, Middeldorp S et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141 (2 Suppl):e691S-736S. PMID: 22315276
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
