The Basics

What is Chloral Hydrate?

Used in the short-term treatment of insomnia and to relieve anxiety and induce sleep before surgery. It is also used after surgery for pain and to treat alcohol withdrawal.

Brand names for Chloral Hydrate

Noctec

How Chloral Hydrate is classified

Hypnotics and Sedatives

Chloral Hydrate During Pregnancy

Chloral Hydrate pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Chloral Hydrate while pregnant

Animal reproduction studies have not been conducted with chloral hydrate. Chloral hydrate crosses the placental barrier and chronic use during pregnancy may cause withdrawal symptoms in the neonate. It is not known whether chloral hydrate can affect reproduction capacity. Chloral hydrate should be given to a pregnant woman only if clearly needed.

Taking Chloral Hydrate While Breastfeeding

What are recommendations for lactation if you're taking Chloral Hydrate?

Short-term or occasional use of chloral hydrate during breastfeeding is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months. Because the active metabolite of chloral hydrate has a long half-life, other sedative-hypnotics are preferred for long-term use during breastfeeding, especially while nursing a neonate or preterm infant. Monitor the infant for excessive drowsiness.

Maternal / infant drug levels

Short-term or occasional use of chloral hydrate during breastfeeding is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months. Because the active metabolite of chloral hydrate has a long half-life, other sedative-hypnotics are preferred for long-term use during breastfeeding, especially while nursing a neonate or preterm infant. Monitor the infant for excessive drowsiness.

Possible effects of Chloral Hydrate on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Chloral Hydrate

Zaleplon, Zolpidem.

List of References

Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Bernstine JB, Meyer AE, Bernstine RL. Maternal blood and breast milk estimation following the administration of chloral hydrate during the puerperium. J Obstet Gynaecol Br Emp. 1956;63:228-31. PMID: 13320217
2. Lacey JH. Dichloralphenazone and breast milk. Br Med J. 1971;4:684. Letter. PMID: 5134581
3. Reed CB. A study of the conditions that require removal of the child from the breast. Surg Gynecol Obstet. 1908;6:514-27.

Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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