The Basics
What is Choline Magnesium Salicylate?
Used to reduce swelling and to treat mild to moderate pain.
Brand names for Choline Magnesium Salicylate
Trilisate
How Choline Magnesium Salicylate is classified
Analgesic Agents, Nonsteroidal Antiinflammatory Agents
Choline Magnesium Salicylate During Pregnancy
Choline Magnesium Salicylate pregnancy category
Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Choline Magnesium Salicylate while pregnant
Animal reproduction studies have not been conducted with TRILISATE (choline magnesium trisalicylate) preparations. It is also not known whether TRILISATE (choline magnesium trisalicylate) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. TRILISATE (choline magnesium trisalicylate) should be given to a pregnant woman only if clearly needed. Because of the known effects of other salicylate drug products on the fetal cardiovascular system (closure of ductus arteriosus), use during late pregnancy should be avoided.
Taking Choline Magnesium Salicylate While Breastfeeding
What are recommendations for lactation if you're taking Choline Magnesium Salicylate?
Choline magnesium salicylate has not been studied during breastfeeding, but choline magnesium salicylate results in salicylic acid in the blood. Salicylic acid and aspirin have been studied during breastfeeding. The excretion of salicylate into breastmilk increases disproportionately as the maternal dosage increases. Long-term, high-dose maternal aspirin ingestion probably caused metabolic acidosis in one breastfed infant. Reye’s syndrome is associated with aspirin administration to infants with viral infections, but the risk of Reye’s syndrome from salicylate in breastmilk is unknown. An alternate drug is preferred over choline magnesium salicylate.
Maternal / infant drug levels
Choline magnesium salicylate has not been studied during breastfeeding, but choline magnesium salicylate results in salicylic acid in the blood. Salicylic acid and aspirin have been studied during breastfeeding. The excretion of salicylate into breastmilk increases disproportionately as the maternal dosage increases. Long-term, high-dose maternal aspirin ingestion probably caused metabolic acidosis in one breastfed infant. Reye’s syndrome is associated with aspirin administration to infants with viral infections, but the risk of Reye’s syndrome from salicylate in breastmilk is unknown. An alternate drug is preferred over choline magnesium salicylate.
Possible effects of Choline Magnesium Salicylate on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Choline Magnesium Salicylate
Acetaminophen, Ibuprofen.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Levy G. Salicylate pharmacokinetics in the human neonate. In, Morselli PL, Garattini S, Sereni F, eds. Basic and therapeutic aspects of perinatal pharmacology. 1975;Raven Press :New York:319-30.
2. Putter J, Satravaha P, Stockhausen H. Quantitative analysis of the main metabolites of acetylsalicylic acid. Comparative analysis in the blood and milk of lactating women. Z Geburtshilfe Perinatol. 1974;178:135-8. PMID: 4422623
3. Jamali F, Keshavarz E. Salicylate excretion in breast milk. Int J Pharm. 1981;8:285-90.
4. Findlay JW, DeAngelis RL, Kearney MF et al. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981;29:625-33. PMID: 7214793
5. Bailey DN, Welbert RT, Naylor A. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol. 1982;6:64-8. PMID: 7098450
6. Unsworth J, d’Assis-Fonseca A, Beswick DT. Serum salicylate levels in a breast fed infant. Ann Rheum Dis. 1987;46:638-9. PMID: 3662653
7. Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate. Clin Pediatr (Phila). 1981;20:53-4. PMID: 7449246
8. Terragna A, Spirito L. [Thrombocytopenic purpura in an infant after administration of acetylsalicylic acid to the wet-nurse] . Minerva Pediatr. 1967;19:613-6.
9. Harley JD, Robin H. Late neonatal jaundice in infants with glucose-6-phosphate dehydrogenase-deficient erythrocytes. Australas Ann Med. 1962;11:148-55. PMID: 13960788
10. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
