Enoxacin

The Basics

What is Enoxacin?

An antibacterial sed in the treatment of urinary tract infections and gonorrhoea.

Brand names for Enoxacin

Penetrex

How Enoxacin is classified

Anti-Infective Agents, Antibacterial Agents, Antibacterial Agents, Fluoroquinolones

Enoxacin During Pregnancy

Enoxacin pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Enoxacin while pregnant

Studies with enoxacin given orally to mice and rats have shown no evidence of teratogenic potential. The intravenous infusion of enoxacin into pregnant rabbits at doses of 10 to 50 mg/kg caused dose-related maternal toxicity (venous irritation, body weight loss, and reduced food intake) and, at 50 mg/kg, fetal toxicity (increased post-implantation loss and stunted fetuses). At 50 mg/kg, the incidence of fetal malformations was significantly increased in the presence of overt maternal and fetal toxicity. There are no adequate and well-controlled studies in pregnant women. Enoxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (See WARNINGS.)

Taking Enoxacin While Breastfeeding

What are recommendations for lactation if you're taking Enoxacin?

Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants’ developing joints. However, recent studies indicate little risk.[1][2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk,[3] but insufficient data exist to prove or disprove this assertion. Use of enoxacin is probably acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). However, it is preferable to use an alternate drug for which safety information is available.

Maternal / infant drug levels

Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants’ developing joints. However, recent studies indicate little risk.[1][2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk,[3] but insufficient data exist to prove or disprove this assertion. Use of enoxacin is probably acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). However, it is preferable to use an alternate drug for which safety information is available.

Possible effects of Enoxacin on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Enoxacin

Ciprofloxacin, Levofloxacin.