The Basics

What is Glimepiride?

Oral diabetes medicine used to improve blood sugar control in adults with type 2 diabetes mellitus.

Brand names for Glimepiride

Amaryl

How Glimepiride is classified

Hypoglycemic Agents, Sulfonylurea Compounds

Glimepiride During Pregnancy

Glimepiride pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Glimepiride while pregnant

N/A

Taking Glimepiride While Breastfeeding

What are recommendations for lactation if you're taking Glimepiride?

Because no information is available on the use of glimepiride during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with glimepiride.[1][2]

Maternal / infant drug levels

Because no information is available on the use of glimepiride during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with glimepiride.[1][2]

Possible effects of Glimepiride on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Glimepiride

Acarbose, Glipizide, Glyburide, Insulin, Metformin, Miglitol.

List of References

Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID: 9429368
2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580

Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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