The Basics

What is Glyburide?

Used to treat type 2 diabetes.

Brand names for Glyburide

Glynase

How Glyburide is classified

Hypoglycemic Agents

Glyburide During Pregnancy

Glyburide pregnancy category

Category BNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Glyburide while pregnant

N/A

Taking Glyburide While Breastfeeding

What are recommendations for lactation if you're taking Glyburide?

Limited data indicate that the levels of glyburide in milk are negligible. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Maternal / infant drug levels

Limited data indicate that the levels of glyburide in milk are negligible. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Possible effects of Glyburide on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Glyburide

Acarbose, Glipizide, Insulin, Metformin, Miglitol.

List of References

Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID: 9429368
2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580
3. Feig DS, Briggs GG, Kraemer JM et al. Transfer of glyburide and glipizide into breast milk. Diabetes Care. 2005;28:1851-5. PMID: 16043722
4. Feig DS, Kraemer JM, Moskovitz DN et al. The transfer of glyburide into breast milk. Clin Pharmacol Ther. 2004;75(2):P24. Abstract.
5. Myngheer N, Allegaert K, Hattersley A et al. Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes. Diabetes Care . 2014;37:3333-5. PMID: 25231897

Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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