The Basics
What is Halofantrine?
Used to treat malaria.
Brand names for Halofantrine
Halfan
How Halofantrine is classified
Anti-infective Agents, Antiparasitic Agents, Antimalarials, Antiprotozoal Agents
Halofantrine During Pregnancy
Halofantrine pregnancy category
Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Halofantrine while pregnant
In pregnant rabbits, maternal-lethal doses (decremental dose schedule of 360 to 120 mg/kg, equivalent to 3.6 times to 1.2 times the maximum recommended human dose, respectively, based on mg/m2) were associated with abortion and an increased incidence of skeletal malformations, but oral doses up to 60 mg/kg (6/10 of the maximum recommended human dose based on mg/m2) did not produce maternal or fetal developmental toxicity.
Taking Halofantrine While Breastfeeding
What are recommendations for lactation if you're taking Halofantrine?
Because no information is available on the use of halofantrine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[1]
Maternal / infant drug levels
Because no information is available on the use of halofantrine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[1]
Possible effects of Halofantrine on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Halofantrine
Chloroquine, Mefloquine.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Chattopadhyay R, Mahajan B, Kumar S. Assessment of safety of the major antimalarial drugs. Expert Opin Drug Saf. 2007;6:505-21. PMID: 17877439
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
