The Basics
What is Isradipine?
Used to treat high blood pressure.
Brand names for Isradipine
Dynacirc
How Isradipine is classified
Antihypertensive Agents, Calcium Channel Blockers, Vasodilator Agents
Isradipine During Pregnancy
Isradipine pregnancy category
Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Isradipine while pregnant
Isradipine was administered orally to rats and rabbits during organogenesis. Treatment of pregnant rats with doses of 6, 20, or 60 mg/kg/day produced a significant reduction in maternal weight gain during treatment with the highest dose (150 times the maximum recommended human daily dose) but with no lasting effects on the mother or the offspring. Treatment of pregnant rabbits with doses of 1,3, or 10 mg/kg/day (2.5, 7.5, and 25 times the maximum recommended human daily dose) produced decrements in maternal body weight gain and increased fetal resorption at the two higher doses. There was no evidence of embryotoxicity at doses which were not maternotoxic and no evidence of teratogenicity at any dose tested. In a peri/postnatal administration study in rats, reduced maternal body weight gain during late pregnancy at oral doses of 20 and 60 mg/kg/day isradipine was associated with reduced birth weights and decreased peri and postnatal pup survival. There are no adequate and well controlled studies in pregnant women. The use of DynaCirc® (isradipine) during pregnancy should only be considered if the potential benefit outweighs potential risks.
Taking Isradipine While Breastfeeding
What are recommendations for lactation if you're taking Isradipine?
Because no information is available on the use of isradipine during breastfeeding, an alternate drug may be preferred.
Maternal / infant drug levels
Because no information is available on the use of isradipine during breastfeeding, an alternate drug may be preferred.
Possible effects of Isradipine on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Isradipine
Nifedipine, Nitrendipine.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/None listed
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
