The Basics
What is Linagliptin?
Used to treat type 2 diabetes.
Brand names for Linagliptin
Tradjenta
How Linagliptin is classified
Hypoglycemic Agents, Incretins, Dipeptidyl-Peptidase IV Inhibitors, DPP-4 Inhibitors
Linagliptin During Pregnancy
Linagliptin pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Linagliptin while pregnant
N/A
Taking Linagliptin While Breastfeeding
What are recommendations for lactation if you're taking Linagliptin?
No information is available on the clinical use of linagliptin during breastfeeding. Linagliptin’s plasma protein binding ranges from 80% to over 99%, so it is unlikely to pass into breastmilk in clinically important amounts and might be a better choice among drugs in this class for nursing mothers. However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with linagliptin.[1]
Maternal / infant drug levels
No information is available on the clinical use of linagliptin during breastfeeding. Linagliptin’s plasma protein binding ranges from 80% to over 99%, so it is unlikely to pass into breastmilk in clinically important amounts and might be a better choice among drugs in this class for nursing mothers. However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant’s blood glucose is advisable during maternal therapy with linagliptin.[1]
Possible effects of Linagliptin on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Linagliptin
Acarbose, Glipizide, Glyburide, Insulin, Metformin, Miglitol.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10: 149-59. PMID: 15701580
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
