Lofexidine

The Basics

What is Lofexidine?

Historically used to treat high blood pressure, but more commonly used to help with the physical symptoms of opioid withdrawal.

Brand names for Lofexidine

N/A

How Lofexidine is classified

Adrenergic Alpha-2 Receptor Agonists, Narcotic Antagonists

Lofexidine During Pregnancy

Lofexidine pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Lofexidine while pregnant

N/A

Taking Lofexidine While Breastfeeding

What are recommendations for lactation if you're taking Lofexidine?

No information is available on the use of lofexidine during breastfeeding. Lofexidine is chemically and pharmacologically related to clonidine, which reaches high levels in milk and in the breastfed infant. Although it is not contraindicated during breastfeeding, lofexidine should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

No information is available on the use of lofexidine during breastfeeding. Lofexidine is chemically and pharmacologically related to clonidine, which reaches high levels in milk and in the breastfed infant. Although it is not contraindicated during breastfeeding, lofexidine should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Lofexidine on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Lofexidine

Buprenorphine, Methadone.