Mometasone, Nasal

The Basics

What is Mometasone, Nasal?

Used to prevent and treat seasonal and year-round allergy symptoms and nasal polyps.

Brand names for Mometasone, Nasal

Nasonex

How Mometasone, Nasal is classified

Anti-Allergic Agents, Anti-Asthmatic Agents, Corticosteroids – Inhaled, Glucocorticoids, Anti-Inflammatory Agents

Mometasone, Nasal During Pregnancy

Mometasone, Nasal pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Mometasone, Nasal while pregnant

Although intranasal mometasone has limited systemic absorption and use in pregnancy is likely acceptable, other agents have more pregnancy data and may be preferred for the treatment of allergic rhinitis in pregnant women. There are no adequate and well-controlled studies in pregnant women. NASONEX Nasal Spray50 mcg, like other corticosteroids, should be used during pregnancy only if the potential benefits justify the potential risk to the fetus. Experience withoral corticosteroids since their introduction in pharmacologic, as opposed to physiologic, doses suggests that rodents are more prone to teratogeniceffects from corticosteroids than humans. In addition, because there is a natural increase in corticosteroid production during pregnancy, most women willrequire a lower exogenous corticosteroid dose and many will not need corticosteroid treatment during pregnancy.In mice, mometasone furoate caused cleft palate at subcutaneous doses (less than the MRDID in adults on a mcg/m2 basis). Fetal survival wasreduced at approximately 2 times the MRDID in adults on a mcg/m2 basis. No toxicity was observed at less than the MRDID in adults on a mcg/m2 basis.In rats, mometasone furoate produced umbilical hernia at topical dermal doses approximately 10 times the MRDID in adults on a mcg/m2 basis.A topical dermal dose approximately 6 times the MRDID in adults on a mcg/m2 basis produced delays in ossification, but no malformations.In rabbits, mometasone furoate caused multiple malformations (e.g., flexed front paws, gallbladder agenesis, umbilical hernia, and hydrocephaly)at topical dermal doses approximately 6 times the MRDID in adults on a mcg/m2 basis. In an oral study, mometasone furoate increased resorptions andcaused cleft palate and/or head malformations (hydrocephaly or domed head) at approximately 30 times the MRDID in adults on a mcg/m2 basis. Atapproximately 110 times the MRDID in adults on a mcg/m2 basis, most litters were aborted or resorbed. No toxicity was observed at approximately 6times the MRDID in adults on a mcg/m2 basis.When rats received subcutaneous doses of mometasone furoate throughout pregnancy or during the later stages of pregnancy, a dose less thanthe MRDID in adults on a mcg/m2 basis caused prolonged and difficult labor and reduced the number of live births, birth weight, and early pup survival.

Taking Mometasone, Nasal While Breastfeeding

What are recommendations for lactation if you're taking Mometasone, Nasal?

Neither inhaled mometasone nor mometasone nasal implants have been studied during breastfeeding. Although not measured, the amounts of nasal corticosteroids absorbed into the maternal bloodstream and excreted into breastmilk are probably too small to affect a breastfed infant. Reviewers and an expert panel consider inhaled corticosteroids acceptable to use during breastfeeding.[1][2][3]

Maternal / infant drug levels

Neither inhaled mometasone nor mometasone nasal implants have been studied during breastfeeding. Although not measured, the amounts of nasal corticosteroids absorbed into the maternal bloodstream and excreted into breastmilk are probably too small to affect a breastfed infant. Reviewers and an expert panel consider inhaled corticosteroids acceptable to use during breastfeeding.[1][2][3]

Possible effects of Mometasone, Nasal on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Mometasone, Nasal

(Inhaled) Beclomethasone, Budesonide.