Moxidectin

The Basics

What is Moxidectin?

Used for the treatment of onchocerciasis.

Brand names for Moxidectin

N/A

How Moxidectin is classified

Anti-Infective Agents, Antiparasitic Agents, Anthelmintics, Antinematodal Agents, Insecticides, Macrolides

Moxidectin During Pregnancy

Moxidectin pregnancy category

Category Not assignedNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Moxidectin while pregnant

Limited available data on the use of Moxidectin Tablets in pregnant women are insufficient to establish whetherthere is a moxidectin-associated risk for major birth defects and miscarriage. Moxidectin administered orally topregnant rats during the period of organogenesis (Gestation Days (GD) 6 to 15), was not associated withsignificant embryo-fetal developmental effects at doses of approximately 15 times the recommended humandose based on body surface area. When moxidectin was dosed orally to pregnant rabbits during the period oforganogenesis (GD 7 – 19), no embryo-fetal developmental effects were observed at oral doses of moxidectinup to 24 times the recommended human dose based on body surface area .Daily parental oral administration of dietary moxidectin to rats prior to mating, and through mating, gestation,and lactation was associated with decreased survival and body weights for first-generation offspring withoutmaternal toxicity at moxidectin doses less than 2-times the recommended human dose based on body surfacearea comparison. Daily dietary moxidectin did not produce maternal toxicity or adverse effects for first- andsecond-generation offspring at doses approximately equivalent to the recommended human dose based on body surface area comparison. Offspring were assessed for survival, body weights, and fertility.Developmental milestones were not assessed in this study.The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.All pregnancies have a background risk of birth defect, loss or other adverse outcomes. In the U.S. generalpopulation, the estimated background risk of major birth defects and miscarriage in clinically recognizedpregnancies is 2% to 4% and 15% to 20%, respectively.

Taking Moxidectin While Breastfeeding

What are recommendations for lactation if you're taking Moxidectin?

Moxidectin was detected in the milk of lactating women following a single 8 mg dose of Moxidectin Tablets. There are no data on the effects of Moxidectin Tablets on the breast-fed infant or milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Moxidectin Tablets and any potential adverse effects on the breastfed child from Moxidectin Tablets or from the underlying maternal condition. Until more data become available, moxidectin should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Moxidectin was detected in the milk of lactating women following a single 8 mg dose of Moxidectin Tablets. There are no data on the effects of Moxidectin Tablets on the breast-fed infant or milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Moxidectin Tablets and any potential adverse effects on the breastfed child from Moxidectin Tablets or from the underlying maternal condition. Until more data become available, moxidectin should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.

Possible effects of Moxidectin on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Moxidectin

None listed