Nisoldipine

The Basics

What is Nisoldipine?

Used to treat high blood pressure.

Brand names for Nisoldipine

Sular

How Nisoldipine is classified

Antihypertensive Agents, Calcium Channel Blockers, Vasodilator Agents

Nisoldipine During Pregnancy

Nisoldipine pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Nisoldipine while pregnant

Nisoldipine was neither teratogenic nor fetotoxic at doses that were not maternally toxic. Nisoldipine was fetotoxic but not teratogenic in rats and rabbits at doses resulting in maternal toxicity (reduced maternal body weight gain). In pregnant rats, increased fetal resorption (postimplantation loss) was observed at 100 mg/kg/day and decreased fetal weight was observed at both 30 and 100 mg/kg/day. These doses are, respectively, about 5 and 16 times the MRHD when compared on a mg/m2 basis. In pregnant rabbits, decreased fetal and placental weights were observed at a dose of 30 mg/kg/day, about 10 times the MRHD when compared on a mg/m2 basis. In a study in which pregnant monkeys (both treated and control) had high rates of abortion and mortality, the only surviving fetus from a group exposed to a maternal dose of 100 mg nisoldipine/kg/day (about 30 times the MRHD when compared on a mg/m2 basis) presented with forelimb and vertebral abnormalities not previously seen in control monkeys of the same strain. There are no adequate and well controlled studies in pregnant women. SULAR should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

Taking Nisoldipine While Breastfeeding

What are recommendations for lactation if you're taking Nisoldipine?

Because no information is available on the use of nisoldipine during breastfeeding, an alternate drug may be preferred.

Maternal / infant drug levels

Because no information is available on the use of nisoldipine during breastfeeding, an alternate drug may be preferred.

Possible effects of Nisoldipine on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Nisoldipine

Nifedipine, Nitrendipine.