Oritavancin

The Basics

What is Oritavancin?

Used to treat skin infections caused by certain types of bacteria.

Brand names for Oritavancin

Orbactiv Iv

How Oritavancin is classified

Anti-Infective Agents, Anti-Bacterial Agents, Glycopeptides, Lipoglycopeptides

Oritavancin During Pregnancy

Oritavancin pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Oritavancin while pregnant

Reproduction studies performed in rats and rabbits have revealed no evidence of harm to the fetus due to oritavancin at the highest concentrations administered, 30 mg/kg/day and 15 mg/kg/day, respectively. Those daily doses would be equivalent to a human dose of 300 mg, or 25% of the single clinical dose of 1200 mg. Higher doses were not evaluated in nonclinical developmental and reproductive toxicology studies. There are no adequate and well-controlled trials in pregnant women. ORBACTIV should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Taking Oritavancin While Breastfeeding

What are recommendations for lactation if you're taking Oritavancin?

Because oritavancin is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Monitor the infant for possible effects on the gastrointestinal tract, such as diarrhea, vomiting, and candidiasis (e.g., thrush, diaper rash). However, because there is no published experience with oritavancin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Because oritavancin is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Monitor the infant for possible effects on the gastrointestinal tract, such as diarrhea, vomiting, and candidiasis (e.g., thrush, diaper rash). However, because there is no published experience with oritavancin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Oritavancin on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Oritavancin

Clindamycin, Daptomycin, Doxycycline, Trimethoprim-Sulfamethoxazole, Vancomycin.