The Basics

What is Pregabalin?

Used to relieve neuropathic pain that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes and postherpetic neuralgia.

Brand names for Pregabalin

Lyrica

How Pregabalin is classified

Analgesics, Anticonvulsants

Pregabalin During Pregnancy

Pregabalin pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Pregabalin while pregnant

N/A

Taking Pregabalin While Breastfeeding

What are recommendations for lactation if you're taking Pregabalin?

Llimited data indicate that amounts of pregabalin in breastmilk are low. If pregabalin is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Llimited data indicate that amounts of pregabalin in breastmilk are low. If pregabalin is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Pregabalin on milk supply

A study randomized pregnant women to either a single dose of pregabalin 150 mg (n = 45), 300 mg (n = 45), or placebo (n = 45) orally 1 hour before induction of anesthesia for an elective cesarean section to reduce postoperative analgesia requirements. Three infants of mothers in the pregabalin 300 mg group had difficulty latching on for breastfeeding for 8 hours after delivery, although none were sedated.[2]

Possible alternatives to Pregabalin

None listed

List of References

Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Ohman I, De Flon P, Tomson T. Pregabalin kinetics in the neonatal period, and during lactation. Epilepsia. 2011;52 (Suppl 6):249-50. Abstract p824. DOI: doi:10.1111/j.1528-1167.2011.03207.x
2. Lockwood PA, Pauer L, Scavone JM et al. The pharmacokinetics of pregabalin in breast milk, plasma, and urine of healthy postpartum women. J Hum Lact. 2016;32:NP1-NP8. PMID: 26961752
3. El Kenany S, El Tahan MR. Effect of preoperative pregabalin on post-caesarean delivery analgesia: A dose-response study. Int J Obstet Anesth. 2016;26:24-31. PMID: 26718698

Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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