The Basics
What is Ravulizumab?
Used to treat paroxysmal nocturnal hemoglobinuria.
Brand names for Ravulizumab
Ultomiris
How Ravulizumab is classified
Antibodies – Monoclonal
Ravulizumab During Pregnancy
Ravulizumab pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Ravulizumab while pregnant
N/A
Taking Ravulizumab While Breastfeeding
What are recommendations for lactation if you're taking Ravulizumab?
No information is available on the use of ravulizumab during breastfeeding. Because ravulizumab is a large protein molecule with a molecular weight of about 148,000, absorption is unlikely because it is probably destroyed in the infant’s gastrointestinal tract. The manufacturer recommends that breastfeeding be discontinued during ravulizumab therapy and for 8 months after the final dose.
Maternal / infant drug levels
No information is available on the use of ravulizumab during breastfeeding. Because ravulizumab is a large protein molecule with a molecular weight of about 148,000, absorption is unlikely because it is probably destroyed in the infant’s gastrointestinal tract. The manufacturer recommends that breastfeeding be discontinued during ravulizumab therapy and for 8 months after the final dose.
Possible effects of Ravulizumab on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Ravulizumab
Eculizumab.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/None listed
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
