Sacubitril

The Basics

What is Sacubitril?

Used together with other medicines to treat chronic heart failure in adults and cut down on the number of hospital visits for heart problems.

Brand names for Sacubitril

Entresto

How Sacubitril is classified

Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, ACE Inhibitors, ACEIs

Sacubitril During Pregnancy

Sacubitril pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Sacubitril while pregnant

ENTRESTO can cause fetal harm when administered to a pregnant woman. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. In animal reproduction studies, ENTRESTO treatment during organogenesis resulted in increased embryo-fetal lethality in rats and rabbits and teratogenicity in rabbits. When pregnancy is detected, consider alternative drug treatment and discontinue ENTRESTO. However, if there is no appropriate alternative to therapy with drugs affecting the reninangiotensin system, and if the drug is considered lifesaving for the mother, advise a pregnant woman of the potential risk to the fetus. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively

Taking Sacubitril While Breastfeeding

What are recommendations for lactation if you're taking Sacubitril?

Sacubitril is available in the United States only in combination with valsartan. Because no information is available on the use of sacubitril or valsartan during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Sacubitril is available in the United States only in combination with valsartan. Because no information is available on the use of sacubitril or valsartan during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Sacubitril on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Sacubitril

Benazepril, Enalapril, Quinapril.