The Basics

What is Smallpox Vaccine?

Protects people from smallpox.

Brand names for Smallpox Vaccine

Na

How Smallpox Vaccine is classified

Vaccines

Smallpox Vaccine During Pregnancy

Smallpox Vaccine pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Smallpox Vaccine while pregnant

N/A

Taking Smallpox Vaccine While Breastfeeding

What are recommendations for lactation if you're taking Smallpox Vaccine?

The Centers for Disease Control and Prevention recommends that nursing mothers not receive the smallpox vaccine, even if they are pumping their milk and feeding it to their infant by bottle feeding. If a woman received smallpox vaccine during pregnancy or breastfeeding, she should avoid breastfeeding and handling any baby for at least 3 to 4 weeks until the vaccination scab has separated from the vaccination site. The breasts can be pumped to maintain the milk supply, but the milk should be discarded.[1][2][3] If a close contact of the nursing mother receives the smallpox vaccine should wash their hands with soap and warm water after direct contact with the vaccination site, or anything that has touched the vaccination site (bandages, clothing, towels, bedding, etc.). This is will help prevent the spread of vaccinia virus to contacts, including young babies. If a breastfeeding mother who has had close contact with a person recently vaccinated against smallpox develops a rash, she should check with her healthcare provider to determine if the rash is related to the smallpox vaccine. If she has a vaccine-related rash, breastfeeding should not take place until all scabs from the rash have fallen off.[3]

Maternal / infant drug levels

The Centers for Disease Control and Prevention recommends that nursing mothers not receive the smallpox vaccine, even if they are pumping their milk and feeding it to their infant by bottle feeding. If a woman received smallpox vaccine during pregnancy or breastfeeding, she should avoid breastfeeding and handling any baby for at least 3 to 4 weeks until the vaccination scab has separated from the vaccination site. The breasts can be pumped to maintain the milk supply, but the milk should be discarded.[1][2][3] If a close contact of the nursing mother receives the smallpox vaccine should wash their hands with soap and warm water after direct contact with the vaccination site, or anything that has touched the vaccination site (bandages, clothing, towels, bedding, etc.). This is will help prevent the spread of vaccinia virus to contacts, including young babies. If a breastfeeding mother who has had close contact with a person recently vaccinated against smallpox develops a rash, she should check with her healthcare provider to determine if the rash is related to the smallpox vaccine. If she has a vaccine-related rash, breastfeeding should not take place until all scabs from the rash have fallen off.[3]

Possible effects of Smallpox Vaccine on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Smallpox Vaccine

List of References

Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Wharton M, Strikas RA, Harpaz R, Rotz LD, Schwartz B, Casey CG et al. Recommendations for using smallpox vaccine in a pre-event vaccination program. Supplemental recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Healthcare Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep. 2003;52:1-16. PMID: 12710832
2. Acambis I. Medication Guide. ACAM2000 Smallpox (Vaccinia) Vaccine, Live. Version 1.0. 2007.
3. Centers for Disease Control and Prevention. Questions and answers about smallpox vaccination while pregnant or breastfeeding. 2009. http://emergency.cdc.gov/agent/smallpox/faq/pregnancy.asp#downloadpage
4. Acambis I. ACAM2000 (Smallpox [Vaccinia] Vaccine, Live) package insert. 2007.
5. Garde V, Harper D, Fairchok MP. Tertiary contact vaccinia in a breastfeeding infant. JAMA. 2004;291:725-7. PMID: 14871916

Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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