Tioconazole

The Basics

What is Tioconazole?

Antifungal medication used to treat infections caused by a fungus or yeast.

Brand names for Tioconazole

Vagistat-1

How Tioconazole is classified

Anti-Infective Agents, Antifungal Agents, Dermatologic Agents

Tioconazole During Pregnancy

Tioconazole pregnancy category

Category C

Note that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Tioconazole while pregnant

Tioconazole hydrochloride had no adverse effects on fetal viability or growth when administered orally to pregnant rats at doses of 55, 110, and 165 mg/kg/day during the period of organogenesis. A drug- related increase in the incidence of dilated ureters, hydroureters, and hydronephrosis observed in the fetuses of this study was transient and no longer evident in pigs raised to 21 days of age. These effects did not occur following intravaginal administration of approximately 10 mg/kg/day in a 2% cream. There was no evidence of major structural anomalies. No embryotoxic or teratogenic effects were observed in rabbits receiving oral dose levels as high as 165 mg/kg/day or daily intravaginal application of approximately 2-3 mg/kg in a 2% tioconazole cream during organogenesis. Tioconazole hydrochloride, like other azole antimycotic agents, causes dystocia in rats when treatment is extended through parturition. Associated effects in rats include prolongation of pregnancy, in utero deaths, and impaired pup survival. The ”no-effect” level for this phenomenon is 20 mg/kg/day orally and approximately 9 mg/kg/day intravaginally. No effect on parturition occurred in rabbits at 50 mg/kg/day orally.

Taking Tioconazole While Breastfeeding

What are recommendations for lactation if you're taking Tioconazole?

Vaginal tioconazole has not been studied during breastfeeding. Other antifungal agents may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Vaginal tioconazole has not been studied during breastfeeding. Other antifungal agents may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Tioconazole on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Tioconazole

Clotrimazole, Miconazole.